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Secrets from inside the womb that could provide clues to miscarriage

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Credit: Dr Eleftheria Pervolaraki

The major structures of a baby's heart form in just four days, according to new research using the latest imaging techniques.

Identifying the precise time when the four chambers of the heart develop opens up the possibility that doctors could eventually be able to monitor babies during this critical phase of their development.

The lead investigator – Dr Eleftheria Pervolaraki from the University of Leeds – hopes the findings will mean that doctors would be able to intervene when a baby's heart fails to grow properly.

She said: "We have identified a critical time of development of the human heart in pregnancy. We now have a map that we can use to interpret problems during development and look at ways of trying to resolve those problems."

The research involved the imaging of 23 fetal hearts with a gestational age range of 95 to 143 days in the womb.

The study, published in the Nature journal Scientific Reports, looked at how the heart developed 13 to 20 weeks into pregnancy. The researchers used the MRI technology, specifically-written algorithms and 3D computer software to visualise the growing heart.

They found that the most remarkable changes occurred over a four day period 124 days into the pregnancy.

Within this short period, the muscle tissue of the heart rapidly organise. Cardiac fibres were laid down to form the helix shape of the heart within which the four chambers of the heart form. Without this essential architecture in place, the fetal heart cannot survive outside the womb.

One in 10 miscarriages is believed to be caused by the failure of the heart to form normally.

Dr Pervolaraki, from the School of Biomedical Sciences at Leeds, said there was a remarkable consistency around that fact that this phase of the heart's development started between the 16 and 17 week point, precisely at 124 days into pregnancy.

The research team, which included collaborators at the Universities of Durham and Edinburgh, also identified a possible mechanism involved in heart development. During the critical four day period, they found increased levels of two proteins: connexin 40 [correct spelling] and connexin 43.

Dr James Dachtler, from Durham University, said: "The expression of connexin 40 and connexin 43 helps cells in the heart to communicate with each other.

"As the amount of these proteins increases, cells can 'speak' to each other more effectively, which is why we believe we observed this structural development of the heart."

The scientists acknowledge that the development timeline of the human heart remains elusive because of the difficulties of measuring development in the womb.

At the moment, doctors can only effectively monitor a baby's heart after 20 weeks into a pregnancy, and by then developmental problems are difficult to resolve.

The research team believe the specialist imaging techniques that they used could be adapted for use in hospital clinics, allowing clinicians to spot whether a baby's heart is failing to form properly.

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The research was funded by the Medical Research Council in the UK and the Lush Prize, a fund set up to promote non-animal research.

Notes to Editors

For further information, please contact David Lewis in the University press office on 0113 343 8059 or by email: [email protected]

The paper can be downloaded here.

(http://www.nature.com/articles/s41598-017-11129-9)

There are images showing the development of the heart over 4 days. They can be downloaded here. The images show the changes of the heart that take place between 124 days into pregnancy and 128 days into pregnancy. (https://drive.google.com/drive/folders/0B691WmQZab8LeFVmYXZYLVRkZ2s?usp=sharing )

University of Leeds

The University of Leeds is one of the largest higher education institutions in the UK, with more than 33,000 students from more than 150 different countries, and a member of the Russell Group of research-intensive universities.

We are a top ten university for research and impact power in the UK, according to the 2014 Research Excellence Framework, and are in the top 100 for academic reputation in the QS World University Rankings 2018. Additionally, the University was awarded a Gold rating by the Government's Teaching Excellence Framework in 2017, recognising its 'consistently outstanding' teaching and learning provision. Twenty-four of our academics have been awarded National Teaching Fellowships – more than any other institution in England, Northern Ireland and Wales – reflecting the excellence of our teaching. http://www.leeds.ac.uk

Media Contact

David Lewis
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http://www.leeds.ac.uk

Related Journal Article

http://dx.doi.org/10.1038/s41598-017-11129-9

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