Thursday, June 1, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Biology

Scientists identify two hormones that burn fat faster, prevent and reverse diabetes in mice

May 1, 2018
in Biology
0
Share on FacebookShare on Twitter
IMAGE

Credit: Elaine Schmidt/UCLA Health

FINDINGS

UCLA geneticists have created a new technique to hunt for hormones that influence how organs and tissues communicate with each other. The method enabled them to find naturally occurring molecules that play major roles in Type 2 diabetes, obesity and cardiovascular disease.

In particular, they discovered:

  • Two hormones called "notum" and "lipocalin-5" that speed up the body's ability to burn fat.
  • Lipocalin-5 protected mice from developing diabetes — or cured the disease after they developed it.
  • Lipocalin-5 also enhanced muscle tissue's ability to metabolize and absorb dietary nutrients, reducing the risk of obesity and diabetes.

The findings could deepen scientists' understanding of the mechanisms behind obesity and common risk factors for heart disease and diabetes.

BACKGROUND

Diseases such as obesity and diabetes disrupt how individual tissues and organs communicate with one another. The technique developed by the UCLA researchers reverses this disruption by pursuing alternate routes of tissue-to-tissue communication.

METHOD

The researchers developed a data-driven approach to unravel the wide array of functions for hormones that circulate in the bloodstream. They initially identified and studied the hormonal networks in mice. Next they tested whether the functions they assigned to the hormones remained consistent in humans. The team discovered a strong overlap between these hormones' functions in mice and humans. By studying how hormonal functions change in people with diabetes and cardiovascular disease, the scientists were able to identify new ways that tissues signal each other and restore normal communication.

IMPACT

Future studies will address how the newly identified hormones in humans communicate between unrelated types of tissue. The investigators will also apply the new method to evaluate tissue-to-tissue communication across different ethnicities and diseases. The hope is to use these hormones as the basis for drug development — specifically to halt development of obesity and Type 2 diabetes.

###

AUTHORS

Authors include Jake Lusis, a professor of human genetics at the David Geffen School of Medicine at UCLA, and Marcus Seldin, a postdoctoral fellow in Lusis' lab. They are available for interviews.

JOURNAL

Cell Metabolism published the findings on May 1.

FUNDING

The research was supported by grants from the National Heart, Lung and Blood Institute and the Leducq Foundation.

Media Contact

Elaine Schmidt
[email protected]
310-267-8323
@uclahealth

http://www.uclahealth.org/

Original Source

http://newsroom.ucla.edu/releases/scientists-identify-new-hormones-that-burn-fat-faster-prevent-and-reverse-diabetes-in-mice

Share25Tweet16Share4ShareSendShare
  • blank

    Why expensive wine appears to taste better

    71 shares
    Share 28 Tweet 18
  • Artificial intelligence system predicts consequences of gene modifications

    67 shares
    Share 27 Tweet 17
  • “You must have a preference”: How does lack of preference affect joint decision-making?

    67 shares
    Share 27 Tweet 17
  • Element creation in the lab deepens understanding of surface explosions on neutron stars

    75 shares
    Share 30 Tweet 19
  • Finally solved! The great mystery of quantized vortex motion

    64 shares
    Share 26 Tweet 16
  • Overfishing linked to rapid evolution of codfish

    64 shares
    Share 26 Tweet 16
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

Element creation in the lab deepens understanding of surface explosions on neutron stars

Why expensive wine appears to taste better

Study finds that eight factors put Black adults at greater risk of early death

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 206 other subscribers

© 2023 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2023 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In