Rich or poor? Where you start in life influences cancer risk in adulthood
(SALT LAKE CITY)–Researchers at Huntsman Cancer Institute (HCI) at the University of Utah announced today the results of a study that found that circumstances in childhood, such as parental occupation at birth and neighborhood income, might be associated with different risks of certain cancers later in life.
HCI researchers and collaborators at Rutgers University in New Jersey and Temple University Health System in Philadelphia analyzed cancer risk and socioeconomic status (SES) of baby boomers (for this study, those born during 1945 – 1959,) in two Utah counties.
Children born to parents with high occupational standing faced higher risks of melanoma (a serious form of skin cancer) and prostate cancer and, for women, greater risks of breast cancer. The study also found that for those born in neighborhoods with low socioeconomic status in relation to those from high status neighborhoods, women faced greater risks of invasive cervical cancer. In these low SES neighborhoods, men faced lower risks of prostate cancer, and overall (both sexes) the risk of melanoma was lower.
The researchers used the Utah Population Database (UPDB), a unique computerized research resource that contains records from many sources, including genealogies, Utah birth and death certificates, hospitalization records, and driver's license data, to analyze cancer incidence of the study group.
The study evaluated data from individuals who were born in Salt Lake and Weber Counties during 1945-1959 and who survived and lived in Utah until at least age 18. Demographic data were linked to cancer incidence information catalogued in the Utah Cancer Registry to evaluate cancer trends in the general population compared to the study group.
According to the senior author Ken Smith, Ph.D., a population health researcher at Huntsman Cancer Institute and a distinguished professor of family studies and population science at the University of Utah, "This study shows that early-life socioeconomic status, based on factors such as parental occupation at birth, may be associated with cancer risk in adulthood. Using this information, we may be able to identify individuals who are at higher risk for cancer due to socioeconomic status at birth, and ideally, work to find strategies to help them manage their cancer risk in adulthood."
Smith noted that the association between SES and breast, cervical, and prostate cancer might reflect SES differences in participation in cancer screening. He also said the importance of critical periods in a child's development may be affected by exposures and living conditions that can lay the foundation for later cancer risk and contribute to social differences in cancer risk.
The results of this study were published in the journal Cancer Epidemiology, Biomarkers, and Prevention on Sept. 21, 2016.
Funding for this study was provided by the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program through a contract with the Utah Cancer Registry #HHSN261201000026C, which is also supported by the Utah Department of Health and the University of Utah. Further funding was provided by the National Cancer Institute P30 CA042014 grant and the Huntsman Cancer Foundation.
About Huntsman Cancer Institute at the University of Utah
Huntsman Cancer Institute (HCI) is one of the world's top academic research and cancer treatment centers. HCI manages the Utah Population Database – the largest genetic database in the world, with more than 16 million records linked to genealogies, health records, and vital statistics. Using this data, HCI researchers have identified several cancer-causing genes, including the genes responsible for melanoma, colon and breast cancer. HCI is a member of the National Comprehensive Cancer Network (a 27-member alliance of the world's leading cancer centers) and is a National Cancer Institute-Designated Comprehensive Cancer Center. HCI treats patients with all forms of cancer and operates several high-risk clinics that focus on melanoma and breast, colon, and pancreas cancers. The HCI Cancer Learning Center for patient and public education contains one of the nation's largest collections of cancer-related publications. The institute is named after Jon M. Huntsman, a Utah philanthropist, industrialist, and cancer survivor.