Researchers report regenerative effects of low-dose growth factors for bone defect healing
New Rochelle, NY, July 27, 2017 — Researchers compared the effects of three bone growth factors to bone morphogenetic protein 2 (BMP2) — the most commonly used agent for repair of large bone defects, which is not without risks at the doses required–and showed significant bone-healing effects including the formation of new blood vessels at low doses relative to BMP2. These findings, which suggest that the osteogenic factors Nell-1, HMGB1, and CCN2 could enhance bone defect repair using biomaterials, without the need to harvest patient tissue, are reported in Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Tissue Engineering website until August 25, 2017.
The article entitled "Nell-1, HMGB1 and CCN2 Enhance Migration and Vasculogenesis, But Not Osteogenic Differentiation Compared to BMP2" is coauthored by Shorouk Fahmy-Garcia, Marjolein van Driel, Janneke Witte-Buoma, Johannes van Leeuwen, Gerjo van Osch, and Eric Farrell, Erasmus Medical Center, Rotterdam, The Netherlends, and Heike Walled, University Hospital Würzburg, Germany. In this study, the researchers directly compared the proteins BMP2, Nell-1, CCN2, and HMGB1 for their ability to recruit endothelial cells to the site of repair, promote the differentiation of two types of progenitor cells (mesenchymal stem cells and fetal osteoblasts) into mature bone cells, and induce the formation of new blood vessels.
"The magnification of our understanding of best growth factor choices for bone repair-including the optimization of dosing to prevent side effects-is adding considerably to our capacity to control outcomes in bone tissue engineering," says Tissue Engineering Co-Editor-in-Chief Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC.
About the Journal
Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-In-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Leadership of Tissue Engineering Parts B (Reviews) and Part C (Methods) is provided by John P. Fisher, PhD, University of Maryland and John A. Jansen, DDS, PhD, Radboud University, respectively. Complete tables of content and a sample issue may be viewed online at the Tissue Engineering website.
Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS).
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News) was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.