Researchers identify genes responsible for loss of lung function

(Boston)–Chronic Obstructive Pulmonary Disease (COPD) is a disease caused by cigarette smoking that reduces lung function and causes difficulty breathing. It is the third leading cause of death worldwide. Current treatments for COPD only affect symptoms, not progression. Identifying who is going to get COPD before they get it is key to figuring out how to intercept the disease at an early stage.

Researchers from Boston University School of Medicine (BUSM) have identified a panel of genes that are active in smokers and ex-smokers who experience faster loss of lung function over time. They believe these genes could be useful to predict which people are most at risk for smoking-related decline in lung function.

“Our discovery that airway genes change before a rapid decline in lung function should give patients with COPD a lot of hope. A test like this could help doctors identify people at risk for COPD before they get it, and help scientists find new treatments to stop the disease before it gets worse,” explained corresponding author Katrina Steiling, MD, MSc, assistant professor of medicine at BUSM.

Smoking, and diseases related to smoking, create changes throughout the airways and lungs. These changes can be detected using a procedure called a bronchoscopy, where a small flexible camera inserted through the nose or mouth is used to collect cells with brushes from the sides of the airways. The researchers tested airway brushings from 134 people who were current or former smokers. They found changes in the activity of specific genes in the people that went on to have more rapid worsening of their lung function several years after that initial airway brushing. Some of the genes were more active in the people who rapidly lost lung function while other genes were less active in these people.

According to the researchers, further study of these genes may provide clues as to what causes rapid lung function decline which could be used to develop to new treatments for preventing the development of COPD. “Being able to identify people most at risk for worsening lung function might also make clinical trials of COPD fighting medications easier, by enriching the trials testing new medications for people most likely to benefit from them,” added co-author Beth Becker, PhD, a recent graduate from BU’s bioinformatics program.

This study further shows another use for the ‘airway field of injury’ hypothesis. “Cigarette smoking causes changes to the cells in the lungs and airways. Because the changes in the airways are similar to those that occur deep inside the lung, testing the cells in the airways can be used to detect diseases deep within the lungs,” added Marc Lenburg, PhD, professor of medicine and pathology and laboratory medicine at BUSM.

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These findings appear online in the journal Thorax.

Funding for this study was provided by the National Institutes of Health/National Heart, Lung, and Blood Institute (ROI HL095388 and ROI HL 118542-01) and Dutch Longfonds Foundation (4.2.16.132JO).

GO reports unrelated personal fees from AstraZeneca and grants from Janssen Pharmaceuticals. PSH reports unrelated grants from Boehringer lngelheim and Galapagos. MvdB reports unrelated research grants from GlaxoSmithKline, TEVA Pharmaceuticals and Chiesi. AS reports unrelated founder’s equity from Metera Pharmaceuticals as well as grants and personal fees from Janssen Research and Development. KS reports grants from CHEST Foundation, unrelated grants from Lungevity Foundation Early Detection Award and royalties from UpToDate. MEL reports unrelated founder’s equity from Metera Pharmaceuticals and unrelated grants from Janssen Research and Development. WT reports unrelated personal fees from pfizer, GSK, Roche Diagnostics/Ventana, Merck Sharp Dohme, Novartis, Lilly Oncology, Boehringer lngelheim, AstraZeneca, Bristol-Myers-Squibb and AbbVie. KS, MEL and AS have US patent 9,677, 138 issued. EJB, KS, MEL and AS have a relevant patent pending (application no. 62/916,431 ).