Researchers discover gene variant associated with esophageal cancer
CLEVELAND – Researchers at University Hospitals Case Medical Center have discovered that a rare genetic mutation is associated with susceptibility to familial Barrett esophagus (FBE) and esophageal cancer, according to a new study published in the July issue of JAMA Oncology.
Amitabh Chak, MD, of University Hospitals Case Medical Center's Seidman Cancer Center and Case Western Reserve University School of Medicine, and colleagues set out to identify novel disease susceptibility variants in FBE in affected individuals from a large multigenerational family.
The team, led by Dr. Chak along with collaborating senior author Kishore Guda, DVM, PhD, of the Case Comprehensive Cancer Center, used targeted next generation gene sequencing to find a rare mutation (S631G) in FBE in the uncharacterized gene VSIG10L that segregated with disease in affected family members. Functional studies revealed that this mutation disrupts maturation of the normal esophageal lining.
"Instances of esophageal cancer are on the rise, and the disease has a poor five-year survival rate of less than 15 percent," said Dr. Chak. "However early detection through screening can prevent the development of esophageal cancer. Further research assessing this gene variant may reveal pathways important for the pathogenesis of BE and esophageal adenocarcinoma, leading to earlier detection and better treatment options."
Affecting up to 6.8 percent of the population, BE is a leading predictor of esophageal cancer. Compared with the general population, patients with BE have an 11-fold higher risk of developing adenocarcinoma of the esophagus. But despite a dramatic increase in the disease over the past four decades, there have been few advances in understanding and improving treatment options.
Discovery of this variant, which is the first susceptibility variant discovered in FBE, reveals novel biology in disease pathogenesis, and indicates early screening and close clinical monitoring for individuals harboring this germline variant.
"This is a step forward in combating this deadly disease as we discovered a new way to categorize those at risk for esophageal adenocarcinoma," says Dr. Chak.
The study is funded through the Barrett's Esophagus Translational Research Network (BETRNet), a $5.4 million grant to Case Western Reserve University School of Medicine. The five-year award supports a research team, led by Dr. Chak, collaborating to develop an understanding of the basis of Barrett's esophagus and its conversion to esophageal carcinoma through genetic, molecular and physiologic studies.
Senior faculty collaborators on the research team included Dr. Chak, Dr. Guda, Sanford Markowitz, MD, PhD, oncologist at UH Case Medical Center Seidman Cancer Center and Ingalls Professor of Cancer Genetics at Case Western Reserve School of Medicine, and Joseph Willis, MD, Vice-Chair of the Department of Pathology at UH and the School of Medicine. First author on the report is Ryan E. Fecteau, PhD. Other collaborators include Jianping Kong, PhD; Adam Kresak, MD; Wendy Brock, RN; Yeunjoo Song, PhD; Hisashi Fujioka, PhD; Robert Elston, PhD; and John P. Lynch, MD, PhD.
About University Hospitals
Founded in May 1866, University Hospitals serves the needs of patients through an integrated network of 18 hospitals, more than 40 outpatient health centers and primary care physician offices in 15 counties throughout Northeast Ohio. At the core of our $4 billion health system is University Hospitals Case Medical Center, ranked among America's best hospitals by U.S. News & World Report. The primary affiliate of Case Western Reserve University School of Medicine, UH Case Medical Center is home to some of the most prestigious clinical and research programs in the nation, including cancer, pediatrics, women's health, orthopaedics, radiology, neuroscience, cardiology and cardiovascular surgery, digestive health, transplantation and genetics. Its main campus includes UH Rainbow Babies & Children's Hospital, ranked among the top children's hospitals in the nation; UH MacDonald Women's Hospital, Ohio's only hospital for women; and UH Seidman Cancer Center, part of the NCI-designated Case Comprehensive Cancer Center at Case Western Reserve University. UH is the second largest employer in Northeast Ohio with 26,000 employees. For more information, go to http://www.UHhospitals.org.