Researchers describe bone marrow stem cell population with potential for repeat transplantation


Credit: ©Mary Ann Liebert, Inc., publishers

New Rochelle, NY, Nov. 9, 2016 – A new study demonstrates that non-blood cell forming stem cells present in human bone marrow play an important role in maintaining the hematopoietic microenvironment, and these stromal cells appear to retain full self-renewal potential after primary and secondary transplantations, according to an article published in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Stem Cells and Development website.

In the article "Human Non-Hematopoietic CD271pos/CD140alow/neg Bone Marrow Stroma Cells Fulfill Stringent Stem Cell Criteria in Serial Transplantations," the bone marrow stromal stem cells (BMSCs) were shown to have the signature characteristics of self-renewing stem cells capable of differentiating into many different types of skeletal cell lines. Coauthors Roshanak Ghazanfari, Hongzhe Li, Dimitra Zacharaki, Hooi Ching Lim, and Stefan Scheding, University of Lund and Skane University Hospital, Lund, Sweden, provided the first demonstration of the self-renewal and differential potential of human BMSCs in a serial transplantation experiment performed in mice.

"This elegant paper employs a unique profile and groundbreaking techniques to demonstrate that a subfraction of adult BMSCs fulfill stem cell criteria in serial transplantations," says Editor-in-Chief Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.


About the Journal

Stem Cells and Development is an authoritative peer-reviewed journal published 24 times per year in print and online. The Journal is dedicated to communication and objective analysis of developments in the biology, characteristics, and therapeutic utility of stem cells, especially those of the hematopoietic system. A complete table of contents and free sample issue may be viewed on the Stem Cells and Development website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Cellular Reprogramming, Tissue Engineering, and Human Gene Therapy. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

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