Recent updates on antimicrobial therapy

The initial chapter of ‘Anti-infective Research and Development: Updates on Infection Mechanisms and Treatments’ covers the mode of action of natural antimycobacterial compounds such as nordihydroguaiaretic acid, α-mangostin and allicin, as well as antimicrobial peptides and their role in the innate and adaptive immune response leading to the decrease of microbial resistance. This is followed by updates on tuberculosis treatment concerning the immunological role of cells (airway epithelial cells, macrophages, neutrophils and T cells) along with their products (chemokines, cytokines) and other processes such as autophagy that influence the outcome of the host immune response to the infection. Contributors have also reviewed the latest knowledge in the cellular and molecular mechanisms that trigger a protective, immune response and the identification of the molecular targets for vaccine development, all of which are a key priority to develop control measures against Babesia species like Babesia bovis and Babesia bigemina.

Additionally, the neuro-endocrine and neuro-immune mechanisms behind host responses against stress and environmental stimuli during infections are also covered in separate chapters. The volume also provides updates related to Helicobacter pylori pathogenesis. The reviews presented in Anti-infective Research and Development provide timely updates for scholars and professionals associated with the field of antimicrobial research and development.

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About the Editor:

Dr. Gloria G. Guerrero is a principal investigator at the Unit of Biological Science, University Autonome of Zacatecas. Dr. Guerrero graduated from the National Autonome of Mexico (UNAM. Mexico City). She did her first post doctorate from the Institute Pasteur campus Lille, France, and a second post doctorate from the Lab of Human Genetic Diseases, Faculty of Medicine Necker, Paris, France. She worked as an academic researcher in the Institute Superiore di Sanita, Rome, Italy. Her recent work has addressed the serological reactivity and/or gene expression studies using microarray technologies as a diagnostic tool in both bovine and human tuberculosis.

Keywords:

antimycobacterial compounds, tuberculosis treatment, Helicobacter pylori, immune response, vaccine development, antimicrobial research and development, pathogenesis

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Faizan ul Haq
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