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Protein kinase signaling network regulation

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Bethesda, MD – The original identification and linkage of kinases to the development of malignant disease opened an entire new field in oncology. The importance and growing interest in kinases and protein phosphorylation mediated signaling networks in cancer continues unabated, as the successful therapeutic targeting of several kinases (e.g. EGFR, BCR-Abl, EML4-ALK) in the clinic has expanded both the discipline and the pharmaceutical industry. Advances in the protein kinase and protein phosphorylation fields over the last few years have begun to transform our understanding of how signaling regulates cell biological responses. Despite these advances, there are still many aspects of kinase and signaling network regulation that are poorly understood, ranging from the structural/allosteric regulation of protein kinase activity to the cross-talk and feedback mechanisms operating to regulate complex signaling network response to stimulation. Speakers at this meeting will discuss novel insights in signaling network regulation ranging from the molecular to network scale. Specific topics include: structural insights on receptor tyrosine kinase regulation, non-catalytic functions of protein kinases, receptor tyrosine kinase cross-talk and the impact on therapeutic development, novel tools developed through protein engineering to monitor and control signaling network activation, new analytical technologies for quantifying signaling network activation, mechanism of resistance to clinical therapeutics, and computational modeling of complex biological signaling networks.

A large number of oral presentations will be selected from the abstracts, and the selected talks, poster presentations, and recreational activities will provide students, postdoctoral fellows, faculty members, and industry scientists opportunities to exchange ideas and formulate new collaborations.

FASEB has announced a total of 36 Science Research Conferences (SRC) in 2016. Registration opens January 7, 2016. For more information about an SRC, view preliminary programs, or find a listing of all our 2016 SRCs, please visit http://www.faseb.org/SRC.

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Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes. In efforts to expand the SRC series, potential organizers are encouraged to contact SRC staff at [email protected] Proposal guidelines can be found at http://www.faseb.org/SRC.

FASEB is composed of 30 societies with more than 125,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

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Robin Crawford, CMP
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