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Home Latest News

Protein derived from bone may help combat osteosarcoma

March 8, 2023
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A study published in the Journal of Orthopaedic Research has identified a bone matrix protein called Secreted phosphoprotein 24 kD (Spp24) that may help to treat osteosarcoma, the most common type of bone cancer.

In experiments conducted in cells and mice, investigators found that Spp24 inhibits the proliferation and invasiveness of osteosarcoma tumor cells and promotes their apoptosis, or death. Mechanistically, Spp24 binds to and neutralizes a protein called bone morphogenetic protein 2, which has tumor enhancing properties.

“Spp24 and its proteolytic products have a number of effects on bone metabolism that have been elucidated to various degrees. They have the potential to be engineered into bone therapeutics, and this anti-tumor effect through bone morphogenetic protein 2 sequestration is only one such example,” said co–corresponding author Haijun Tian, MD, PhD, of Shanghai Jiao Tong University School of Medicine. “Like many other bone matrix proteins, the more we look into the function of Spp24, the more surprising roles we find even though the primary function of Spp24 remains uncertain.”

URL upon publication: https://onlinelibrary.wiley.com/doi/10.1002/jor.25517

 

Additional Information
NOTE: 
The information contained in this release is protected by copyright. Please include journal attribution in all coverage. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, [email protected]

About the Journal
The Journal of Orthopaedic Research®, a publication of the Orthopaedic Research Society (ORS), is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research, including life sciences, engineering, translational, and clinical studies.

About Wiley
Wiley is one of the world’s largest publishers and a global leader in scientific research and career-connected education. Founded in 1807, Wiley enables discovery, powers education, and shapes workforces. Through its industry-leading content, digital platforms, and knowledge networks, the company delivers on its timeless mission to unlock human potential. Visit us at Wiley.com. Follow us on Facebook, Twitter, LinkedIn and Instagram.



Journal

Journal of Orthopaedic Research®

DOI

10.1002/jor.25517

Article Title

Secreted phosphoprotein 24 kD (Spp24) inhibits the growth of human osteosarcoma through the BMP‐2/Smad signaling pathway

Article Publication Date

8-Mar-2023

Tags: bonecombatderivedosteosarcomaprotein
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