A groundbreaking study has unveiled a powerful approach to precisely dissect the effects of genetic variants at an unprecedented resolution, leveraging CRISPR base editing combined with single-cell transcriptomics. This method, termed CRAFTseq, convincingly demonstrates how subtle regulatory genetic variants can be functionally validated and quantified within complex cellular environments, overcoming limitations of bulk analyses that … Continue reading Precisely Mapping Disease Variant Effects in CRISPR Cells