Thursday, June 1, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Chemistry AND Physics

Polymer synthesis gets a jolt of caffeine

April 13, 2018
in Chemistry AND Physics
0
Share on FacebookShare on Twitter
IMAGE

Credit: Courtesy of the researchers

CAMBRIDGE, MA — Caffeine is well-known for its ability to help people stay alert, but a team of researchers at MIT and Brigham and Women's Hospital has now come up with a novel use for this chemical stimulant — catalyzing the formation of polymer materials.

Using caffeine as a catalyst, the researchers have devised a way to create gummy, biocompatible gels that could be used for drug delivery and other medical applications.

"Most synthetic approaches for synthesizing and cross-linking polymeric gels and other materials use catalysts or conditions that can damage sensitive substances such as biologic drugs. In contrast, here we used green chemistry and common food ingredients," says Robert Langer, the David H. Koch Institute Professor at MIT and one of the study's senior authors. "We believe these new materials could be useful in creating new medical devices and drug delivery systems."

In their paper, which appears the journal Biomaterials, the researchers demonstrated that they could load the gels with two antimalarial drugs, and they expect the material could also be used to carry other types of drugs. Drugs carried by this kind of material could be chewable or easier to swallow, the researchers say.

"It's really appealing for patient populations, especially children, who have difficulty with swallowing capsules and tablets," says Giovanni Traverso, a research affiliate at MIT's Koch Institute for Integrative Cancer Research and a gastroenterologist and biomedical engineer at Brigham and Women's Hospital, who is also a senior author of the paper.

Former MIT postdoc Angela DiCiccio, who is now at Verily Life Sciences, the life sciences division of Google X, is the lead author of the paper.

Caffeine surge

Making polymer gels usually requires metal catalysts, which could be hazardous if any of the catalyst remains in the material after the gel is formed. The MIT team wanted to come up with a new way to make gels using catalysts and starting materials that are based on food products and other materials that are safe to ingest.

"Our goal was to try to simplify the method of manufacturing and impart an improved safety profile from the beginning by using potentially safer catalysts," Traverso says.

Although caffeine has not been used for chemical synthesis before, it drew the researchers' attention because it is plant-derived and can act as a weak base, meaning that it gently removes protons from other molecules. It also has a similar structure to some other organic weak bases that have been used to catalyze the type of chemical reaction needed to form these gels — the formation of ester bonds to create a polyester.

"Polyesters allow for the intentional design of ingestible materials made from bioderived resources," DiCiccio says. "However, there didn't exist any catalysts that were mild enough to enchain these molecules without causing unwanted reactions or requiring super high heat. Our new platform provides an elegant solution to this problem using inexpensive materials and broadly accessible chemistries."

The researchers decided to use caffeine to induce citric acid, another edible material produced by plants, to form a polymer network along with polyethylene glycol (PEG), a biocompatible polymer that has been used in drugs and consumer products such as toothpaste for many decades.

When mixed with citric acid and PEG, and slightly heated, caffeine opens up an oxygen-containing ring in the PEG, allowing it to react with citric acid to form chains that consist of alternating molecules of PEG and citric acid. If drug molecules are present in the mixture, they also become incorporated into the chains.

Mix and match

The researchers showed that they could load two malaria drugs, artesunate and piperaquine, into these polymers. They could also vary the chemical and mechanical properties of the gel by altering its composition. They created gels that contain either PEG or another polymer called polypropylene glycol, as well as some that combine those two polymers in different ratios. This allows them to control properties such as the material's strength, its surface structure, and the rate at which the drugs are released.

"Depending on what the application may be, or what drugs are being incorporated, you could mix and match to find an optimal mixture," Traverso says.

The gels can also be imprinted with patterns such as the microscale architecture found on the surface of lotus leaves, which allows them to repel water. Altering the surface traits of the material could help researchers control how quickly or slowly the gels move through the digestive tract.

The resulting gels contain a small amount of caffeine, roughly the same as that found in a cup of tea. In preliminary safety tests, the researchers found no harmful effects in four types of human cells, or in rats.

###

The research was funded by the Bill and Melinda Gates Foundation, the National Institutes of Health, and the Alexander von Humboldt Foundation. Other MIT authors of the paper include Young-Ah Lucy Lee, Dean Glettig, Elizabeth Walton, Eva de La Serna, Veronica Montgomery, and Tyler Grant.

Media Contact

Sarah McDonnell
[email protected]
617-253-8923
@MIT

http://web.mit.edu/newsoffice

Original Source

http://news.mit.edu/2018/polymer-synthesis-gets-jolt-caffeine-0413

Share25Tweet16Share4ShareSendShare
  • blank

    Why expensive wine appears to taste better

    71 shares
    Share 28 Tweet 18
  • Artificial intelligence system predicts consequences of gene modifications

    67 shares
    Share 27 Tweet 17
  • “You must have a preference”: How does lack of preference affect joint decision-making?

    67 shares
    Share 27 Tweet 17
  • Finally solved! The great mystery of quantized vortex motion

    64 shares
    Share 26 Tweet 16
  • New 3D printing technique ready to advance manufacturing

    64 shares
    Share 26 Tweet 16
  • Element creation in the lab deepens understanding of surface explosions on neutron stars

    75 shares
    Share 30 Tweet 19
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

Element creation in the lab deepens understanding of surface explosions on neutron stars

Why expensive wine appears to taste better

Study finds that eight factors put Black adults at greater risk of early death

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 206 other subscribers

© 2023 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2023 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In