Peering deep into the cell to reveal essential components in cell division

(University of Tsukuba) The nucleolus has been shown to disassemble at the onset of mitosis; however, the relationship between cell cycle progression and nucleolar integrity remains unclear. Japanese researchers recently found that the depletion of NOL11 delayed entry into the mitotic phase and reduced ribosomal RNA levels, leading to caused nucleolar disruption during interphase. The findings suggest that maintenance of nucleolar integrity during interphase is essential for proper cell cycle progression to mitosis.