Pathology Atlas to be previewed at AACR17
A demo version of a new Pathology Atlas will be presented on April 2-5 at the annual meeting of American Association of Cancer Research (AACR17) in Washington, DC. Launched by the Human Protein Atlas consortium in Sweden, the new atlas provides researchers information about the relationship of expression levels of human genes with the clinical outcome in nearly 8,000 cancer patients.
All major cancers have been analyzed, including cancers such as colorectal, renal, liver, breast, lung and prostate. Human Protein Atlas Director Mathias Uhlén, who will speak at the conference, says the Pathology Atlas is based on the integration of publicly available data from The Cancer Genome Atlas and "in-house" data generated within the framework of the Human Protein Atlas project.
"Cancer is one of the leading causes of death worldwide and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors," he says. "The Pathology Atlas provides researchers the possibility to explore the effect of individual genes and the consequences of high and low expression for the survival of a given cancer patient."
More than 500,000 survival (Kaplan-Meier) curves and underlying clinical metadata for all patients are presented in an interactive database. The analysis also includes personalized metabolic modelling of each tumor to facilitate cancer research aimed at developing novel individual treatment schemes based on precision cancer medicine strategies.
"We are excited to launch this knowledge resource for cancer-related research and to enable scientists to study the effect of the genetic make-up of individual tumors and the clinical effect of these changes," Uhlén says.
The Pathology Atlas will be released to the public later this year in conjunction with the publication of an accompanied scientific publication. The new knowledge resource will be available without restriction based an open access policy.
Join us at AACR17 for a personalized demonstration of the Pathology Atlas in our booth #3329 in the non-profit sector of the exhibition. In addition, the preview will also be available in the Atlas Antibodies booth #846.
For further questions contact Frida Henningson Johnson, Communications Officer [email protected], +46-736-494476
The Human Protein Atlas project was initiated in 2003 by Professor Mathias Uhlén and funded by the Knut and Alice Wallenberg foundation. Primarily based in Sweden, the Human Protein Atlas project involves the joint efforts of KTH Royal Institute of Technology in Stockholm, Uppsala University, Uppsala Akademiska University Hospital and more recently also Science for Life Laboratory based in both Uppsala and Stockholm. Formal collaborations are with groups in India, South Korea, Japan, China, Germany, France, Switzerland, USA, Canada, Denmark, Finland, The Netherlands, Spain and Italy.
Frida Henningson Johnson