Novel radiopharmaceutical tracks ‘master switch’ protein responsible for cancer growth

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IMAGE

Credit: Image created by C Beinat et. al, Stanford University, Stanford, CA.

Reston, VA (Embargoed until 7:30 p.m. EDT, Monday, June 14, 2021)–A protein that is critical in cancer cell metabolism has been imaged for the first time with a newly developed radiopharmaceutical, 18F-DASA-23. Imaging with this novel agent has the potential to improve the assessment of treatment response for patients, specifically those with brain tumors. This study was presented at the Society of Nuclear Medicine and Molecular Imaging 2021 Annual Meeting.

Tumor cells go through various changes to survive and prosper in the body. One of the key changes they make is modifying a master switch, known as pyruvate kinase M2 (PKM2). PKM2 controls cell metabolism and allows the cell to make more of the building blocks necessary for cell division.

“Until now we’ve had no way to assess the presence or activity levels of the PKM2 protein involved in that switch,” said Corinne Beinat, PhD, instructor of radiology in the Radiology/Molecular Imaging Program at Stanford University in Stanford, California. “Through the development of 18F-DASA-23, this is the first time we can noninvasively interrogate the biochemistry of a tumor with respect to this master switch PKM2.”

The study focused on patients with glioblastoma brain tumors, as normal brain cells have very low levels of PKM2. Healthy volunteers and patients with glioblastoma underwent positron emission tomography/magnetic resonance imaging with 18F-DASA-23. The radiopharmaceutical was successful in visualizing PKM2 in glioblastoma patients, while it was rapidly cleared from the bodies of healthy volunteers.

“This radiopharmaceutical can be very beneficial in assessing whether brain tumor treatments are working,” stated Beinat. “For example, if a brain tumor is treated with a drug and then imaged with 18F-DASA-23, we can potentially know very quickly whether the therapeutic approach is working. If it’s not effective, we won’t have to waste more time waiting to see if the tumor itself is shrinking.”

She added that 18F-DASA-23 could also possibly be used in other cancers or to learn more about how normal tissues adjust their metabolism during development or in response to varied environmental conditions.

Abstract 99. “Initial Clinical Evaluation of [18F]DASA-23, a PET Imaging Tracer for Evaluation of Aberrantly Expressed Pyruvate Kinase M2 in Glioblastoma,” Corinne Beinat, Chirag Patel, Tom Haywood, Lewis Naya, Jessa Castillo, Bin Shen, Tarik Massoud, Andrei Iagaru, Guido Davidzon, Lawrence Recht and Sanjiv Gambhir, Stanford University, Stanford, California.

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All 2021 SNMMI Annual Meeting abstracts can be found online at https://jnm.snmjournals.org/content/62/supplement_1.

About the Society of Nuclear Medicine and Molecular Imaging

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and medical organization dedicated to advancing nuclear medicine and molecular imaging, vital elements of precision medicine that allow diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.

SNMMI’s members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice. For more information, visit http://www.snmmi.org.

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