Novel method for precise, controllable cell deposition onto tissue engineering constructs

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Credit: Mary Ann Liebert, Inc., publishers

New Rochelle, NY, October 17, 2018–A new study presents a novel method of using a microfluidic flow cell array to achieve precise and reproducible control of cell deposition onto engineered tissue constructs to produce tunable cell patterns and generate essential integration zones. This microfluidic flow cell array cell deposition method, used to generate engineered musculoskeletal tissues, is described in an article in Tissue Engineering, Part C, Methods, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the full-text article free on the Tissue Engineering website through November 18, 2018.

David Ede, Alejandro Blitch, Niloofar Farhang, and Robby Bowles, University of Utah, and Nikki Davidoff, Carterra, describe how they use this new method to create stable integrating cell populations and controlled cell gradients in the article entitled "Microfluidic Flow Cell Array for Controlled Cell Deposition in Engineered Musculoskeletal Tissues." They present the methods developed for deposition of human adipose derived stem cells and human osteoblasts using a 12-channel pilot printhead, and describe how microfluidic flow cell array cell deposition could be used to create an extensive variety of engineered musculoskeletal tissues.

"The described microfluidic method is an important step forward in the engineering of tissues, like cartilage and tendons, which need for their attachment to bone a fibrocartilaginous transition layer," says Methods Co-Editor-in-Chief John A. Jansen, DDS, PhD, Professor and Head, Department of Biomaterials, Radboud University Medical Center, The Netherlands.

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About the Journal

Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-in-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and John P. Fisher, PhD, Fischell Family Distinguished Professor & Department Chair, and Director of the NIH Center for Engineering Complex Tissues at the University of Maryland, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Leadership of Tissue Engineering Parts B (Reviews) and Part C (Methods) is provided by Katja Schenke-Layland, PhD, Eberhard Karls University, Tübingen and John A. Jansen, DDS, PhD, Radboud University, respectively. Complete tables of content and a sample issue may be viewed online at the Tissue Engineering website. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed on the Tissue Engineering website.

About the Publisher

Mary Ann Liebert, Inc., publishers (https://www.liebertpub.com/) is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

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Original Source

https://home.liebertpub.com/news/researchers-develop-novel-method-for-precise-controllable-cell-deposition-onto-tissue-engineering-constructs/2455 http://dx.doi.org/10.1089/ten.tec.2018.0184

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