Novel diagnostic approach could lead to earlier diagnosis of Parkinson’s disease
Parkinson's disease is the second most common neurodegenerative disorder in humans, after Alzheimer's disease. It is typically characterized by changes in motor control such as tremors and shaking, but can also include non-motor symptoms, from the cognitive to the behavioral. An estimated seven to 10 million people worldwide are living with Parkinson's disease, with medication costing approximately $2,500 a year, and therapeutic surgery costing up to $100,000 dollars, per patient.
Making an accurate diagnosis of Parkinson's, particularly in early stages and mild cases, is difficult, and there are currently no standard diagnostic tests other than clinical information provided by the patient and the findings of a neurological exam. One of the best hopes for improving diagnosis is to develop a reliable test for identifying changes in the severity of the disease. This will allow drug companies to test potential drugs at higher efficacy.
Now, a novel diagnostic approach developed at the Hebrew University of Jerusalem's Faculty of Medicine could pave the way toward such a test. Working under the supervision of Dr. Ronit Sharon, at the Institute for Medical Research Israel-Canada (IMRIC), PhD student Suaad Abd-Elhadi developed the lipid ELISA, an approach that could lead to earlier detection of Parkinson's, along with better tracking of the disease's progression and a patient's response to therapy.
How the ELISA works
ELISA stands for "enzyme-linked immunosorbent assay." An assay is a procedure used in laboratory settings to assess the presence, amount and activity of a target entity, such as a drug, cell or biochemical substance. ELISA is a common assay technique that involves targeting cellular secretions.
In the case of the lipid ELISA, the cellular secretion of interest is a specific protein called the alpha-Synuclin protein. This protein serves as a convenient biomarker that is closely associated with the tissues where Parkinson's disease can be detected, along with the neurological pathways the disease travels along, causing its characteristic symptoms.
The development of a simple and highly sensitive diagnostic tool that can detect Parkinson's biomarkers could lead to a minimally invasive and cost-effective way to improve the lives of Parkinson's patients. Toward this end, Abd-Elhadi has recently demonstrated a proof of concept to the high potential of the lipid-ELISA assay in differentiating healthy and Parkinson's affected subjects. She is now in the process of analyzing a large cohort of samples, including moderate and severe Parkinson's, and control cases, as part of a clinical study.
The Hebrew University, which holds granted patents on the technology through its technology transfer company Yissum, has signed an agreement with Integra Holdings for further development and commercialization.
2017 Kaye innovation Award
In recognition of her work, Suaad Abd-Elhadi was awarded the Kaye Innovation Award for 2017.
The Kaye Innovation Awards at the Hebrew University of Jerusalem have been awarded annually since 1994. Isaac Kaye of England, a prominent industrialist in the pharmaceutical industry, established the awards to encourage faculty, staff and students of the Hebrew University to develop innovative methods and inventions with good commercial potential, which will benefit the university and society. For more information about the 2017 Kaye Innovations Awards, visit http://bit.ly/kaye2017.
Suaad Abd-Elhadi is a direct-track Ph.D. student at the Department of Biochemistry and Molecular Biology of the institute for Medical Research Israel-Canada in the Hebrew University's Faculty of Medicine. Under the supervision of Dr. Ronit Sharon, she conducts research that has been published in Scientific Reports and Analytical and Bioanalytical Chemistry. She completed her BSc in medical laboratory science at Hadassah Academic College, and was awarded a scholarship from the Liba and Manek Teich Endowment Fund for Doctoral Students and an Adrian Sucari Scholarship for Academic Excellence.
About the Hebrew University of Jerusalem
The Hebrew University of Jerusalem, Israel's leading academic and research institution, is ranked among the top 100 universities in the world. Founded in 1918 by visionaries including Albert Einstein, the Hebrew University is a pluralistic institution where science and knowledge are advanced for the benefit of humankind. For more information, please visit http://new.huji.ac.il/en.