New regulatory axis revealed for the cancer relevant matrix metalloprotease MMP14

(University of Helsinki) Membrane-associated metalloprotease, MMP14, plays a significant role in different cancer tissues — for instance in breast cancer and melanoma patients high MMP14 levels increase the risk to develop metastasis. The study, conducted at the University of Helsinki, revealed that Prox1 negatively regulates MMP14 protein levels by suppressing transcription of the MMP14 gene.