New protein discovered in aging and cancer
A protein has been found to have a previously unknown role in the ageing of cells, according to an early study by Queen Mary University of London (QMUL). The researchers hope that the findings could one day lead to new treatments for ageing and early cancer.
The organs and tissues in our bodies are formed by a vast number of cells, which altogether co-ordinate their actions for our body to function properly. However, a number of 'abnormal' cells have previously been found in tissues derived from old patients and at the initial stages of cancer.
These particular cells suffer a growth arrest termed 'senescence', which is thought to affect how the tissue functions. Senescent cells fail to proliferate, but they manage to communicate with their neighbouring cells, mainly through the release of inflammatory proteins.
The study, published in Cell Reports, describes a new way that senescent cells communicate, which is via the expression of integrin membrane proteins, including a protein called 'integrin beta 3' which is highly expressed during senescence.
Lead researcher Dr Ana O'Loghlen from QMUL's Blizard Institute, said: "This is the first time that integrin beta 3 has been identified in the context of senescence and ageing, and could be in the future a potential therapeutic target during early carcinogenesis and ageing.
"This finding is particularly interesting, as there is actually a drug against integrin beta 3, called 'cilengitide', that averts one of the disadvantages of ageing in our model – inflammation. It does this without increasing cell proliferation, which is an advantage, as an increase in cell proliferation imposes a risk for cancer."
The study was performed using human primary fibroblasts and fibroblast cells derived from young and old human donors.
The researchers discovered how integrin beta 3 was regulated and the signaling mechanism it uses to transmit senescence to surrounding cells. They could also see that integrin beta 3 was 'upregulated' in a subset of tissue from mice, confirming the importance of their results in two different species.
The study was funded by the Medical Research Council and Biotechnology and Biological Sciences Research Council.
For more information, please contact:
Joel Winston, Public Relations Manager (School of Medicine and Dentistry)
Queen Mary University of London
Tel: +44 (0)20 7882 7943 / +44 (0)7970 096 188
Notes to the editor
Research paper: 'Integrin beta 3 regulates cellular senescence by activating the TGFβ pathway'. Valentina Rapisarda, Michela Borghesan, Veronica Miguela, Vesela Encheva, Ambrosius P Snijders, Amaia Lujambio and Ana O'Loghlen. Cell Reports 2017. DOI: 10.1016/j.celrep.2017.02.012. The paper will publish here after the embargo lifts: http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30177-8
About Queen Mary University of London
Queen Mary University of London (QMUL) is one of the UK's leading universities and one of the largest institutions in the University of London, with 23,120 students from more than 162 countries.
A member of the Russell Group, we work across the humanities and social sciences, medicine and dentistry, and science and engineering, with inspirational teaching directly informed by our research. In the most recent national assessment of research quality, we were placed ninth in the UK (Research Excellence Framework 2014).
As well as our main site at Mile End – home to one of the largest self-contained residential campuses in London – we have campuses at Whitechapel, Charterhouse Square, and West Smithfield dedicated to the study of medicine, and a base for legal studies at Lincoln's Inn Fields.
This year, we are proud to celebrate our 130th anniversary. Queen Mary began life as the People's Palace, a Victorian philanthropic project design to bring culture, recreation and education to the East End. We also have roots in Westfield College, one of the first colleges to provide higher education to women; St Bartholomew's Hospital, one of the first public hospitals in Europe; and The London, one of England's first medical schools.
Today, as well as retaining these close connections to our local community, we are known for our international collaborations in both teaching and research.