Sunday, September 24, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home Latest News

New glioma drug exploits DNA repair defects to selectively target drug-resistant tumors

July 28, 2022
in Latest News
0
Share on FacebookShare on Twitter

A new class of glioma drugs exploits tumors that lack the DNA repair enzyme MGMT; the drugs lead to the generation of cytotoxic DNA and selectively kill tumor cells without the risk of resistance, researchers report. The new approach may lead to new glioma treatments and may represent a new paradigm for designing therapeutics that exploit specific DNA repair defects to combat drug-resistant tumors. Fast-growing and highly aggressive, glioblastoma (GBM) is the most common form of malignant brain tumor. It is also one of the most lethal cancers, with only 1 in 20 patients surviving for 5 years after diagnosis. Although this cancer is treated with a combination of radiotherapy and the chemotherapy drug temozolomide (TMZ), drug resistance develops in many patients. As such, there is a dire need for new GBM treatments. Many GBM and glioma tumors lack the DNA repair protein MGMT – an attribute implicated in their ability to gain drug resistance. Here, Kingson Lin and colleagues present a new therapeutic approach, which leverages this lack of MGMT to kill GBM tumor cells selectively. Using a mechanism-based design approach, Lin et al. developed TMZ analogs that create a dynamic primary DNA lesion, which can be repaired in healthy cells with intact MGMT-mediated DNA repair mechanisms. However, cancer cells lacking MGMT expression cannot repair the damage. In these cells, the primary lesions slowly evolve, creating more and more toxic secondary DNA lesions that result in the selective killing of MGMT-deficient tumor cells. The authors found that the drug-induced selective tumor-cell killing had an acceptable toxicity profile in vitro and in vivo using a mouse model of TMZ-resistant human GBM. In a related Perspective, Roger Reddel and Adel Aref further discuss the study’s findings.



Journal

Science

DOI

10.1126/science.abn7570

Article Title

Mechanism-based design of agents that selectively target drug-resistant glioma

Article Publication Date

29-Jul-2022

Tags: defectsDNADrugdrugresistantexploitsgliomarepairselectivelytargettumors
Share26Tweet16Share4ShareSendShare
  • Null results research now published by major behavioral medicine journal

    1038 shares
    Share 415 Tweet 260
  • New findings on hair loss in men

    68 shares
    Share 27 Tweet 17
  • Tirzepatide more effective in blood sugar control and body weight loss than semaglutide, shows meta-analysis of 22 studies

    64 shares
    Share 26 Tweet 16
  • Astronomers discover newborn galaxies with the James Webb Space Telescope

    64 shares
    Share 26 Tweet 16
  • Chromosome-scale genome sequence of Suaeda glauca sheds light on salt stress tolerance in halophytes

    63 shares
    Share 25 Tweet 16
  • ISSCR Kicks off São Paulo International Symposium today in Ribeirão Preto, Brazil

    64 shares
    Share 26 Tweet 16
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

Null results research now published by major behavioral medicine journal

Corning® launches Videodrop, revolutionizing real-time nanoparticle detection and analysis

Grant awarded to University of Louisville law professor will fund climate adaptation project

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 208 other subscribers

© 2023 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2023 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In