New genetic variations discovered
A University of Wisconsin-Milwaukee researcher is a senior co-author of paper published in the journal Nature Genetics that identifies 17 rare human genetic variations associated with risk factors for diseases such as heart disease and diabetes.
Paul Auer, an assistant professor of biostatistics in the Joseph J. Zilber School of Public Health, worked with scientists from the Wellcome Trust Sanger Institute in Cambridge, England, and other collaborators. In his work, Auer uses mathematics and computers to help understand the genetic basis of human disease.
The study shows how large scale genomic datasets can be used to help identify potential novel biological targets for studying cardiovascular and other diseases, according to information from the Sanger Institute. Professor Nicole Soranzo of the Sanger Institute is joint senior author.
The paper is available at Nature Genetics.
Materials provided by University of Wisconsin-Milwaukee.
Valentina Iotchkova, Jie Huang, John A Morris, Deepti Jain, Caterina Barbieri, Klaudia Walter, Josine L Min, Lu Chen, William Astle, Massimilian Cocca, Patrick Deelen, Heather Elding, Aliki-Eleni Farmaki, Christopher S Franklin, Mattias Franberg, Tom R Gaunt, Albert Hofman, Tao Jiang, Marcus E Kleber, Genevieve Lachance, Jian’an Luan, Giovanni Malerba, Angela Matchan, Daniel Mead, Yasin Memari, Ioanna Ntalla, Kalliope Panoutsopoulou, Raha Pazoki, John R B Perry, Fernando Rivadeneira, Maria Sabater-Lleal, Bengt Sennblad, So-Youn Shin, Lorraine Southam, Michela Traglia, Freerk van Dijk, Elisabeth M van Leeuwen, Gianluigi Zaza, Weihua Zhang, Najaf Amin, Adam Butterworth, John C Chambers, George Dedoussis, Abbas Dehghan, Oscar H Franco, Lude Franke, Mattia Frontini, Giovanni Gambaro, Paolo Gasparini, Anders Hamsten, Aaron Issacs, Jaspal S Kooner, Charles Kooperberg, Claudia Langenberg, Winfried Marz, Robert A Scott, Morris A Swertz, Daniela Toniolo, Andre G Uitterlinden, Cornelia M van Duijn, Hugh Watkins, Eleftheria Zeggini, Mathew T Maurano, Nicholas J Timpson, Alexander P Reiner, Paul L Auer, Nicole Soranzo. Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nature Genetics, 2016; DOI: 10.1038/ng.3668