New approach to treating infectious diseases as an alternative to antibiotics

(Osaka University) Osaka University-led researchers clarified how pathogenic E. coli bacteria attached to the host intestinal epithelium. They revealed that type IV pili on the surface of the bacteria were not sufficient for adherence to intestinal epithelial cells and that proteins secreted by E.coli were also necessary. It was found that this attachment mechanism might be a common feature in many enteropathogens such as Vibrio cholera and constitutes a novel therapeutic target against such bacterial pathogens.

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