Sunday, May 28, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Biology

Neuronal plasticity in chronic pain-induced anxiety revealed

April 27, 2022
in Biology
0
Share on FacebookShare on Twitter

Hokkaido University researchers have shown how chronic pain leads to maladaptive anxiety in mice, with implications for treatment of chronic pain-related psychiatric disorders in humans.

Neuronal circuit involved in chronic pain-induced maladaptive anxiet

Credit: Naoki Yamauchi, et al. Science Advances. April 27, 2022

Hokkaido University researchers have shown how chronic pain leads to maladaptive anxiety in mice, with implications for treatment of chronic pain-related psychiatric disorders in humans.

Chronic pain is persistent and inescapable, and can lead to maladaptive emotional states. It is often comorbid with psychiatric disorders, such as depression and anxiety disorders. It is thought that chronic pain causes changes in neural circuits, and gives rise to depression and anxiety.

Researchers at Hokkaido University have identified the neuronal circuit involved in chronic pain-induced anxiety in mice. Their research, which was recently published in Science Advances, could lead to the development of new treatments for chronic pain and psychiatric disorders such as anxiety disorders and major depressive disorder. 

“Clinicians have known for a long time that chronic pain often leads to anxiety and depression, however the brain mechanism for this was unclear,” said Professor Masabumi Minami of the Faculty of Pharmaceutical Sciences at Hokkaido University, the corresponding author of the paper.

The researchers looked at how neuronal circuits were affected by chronic pain in mice. They used an electrophysiological technique to measure the activities of neurons after four weeks of chronic pain. They found that chronic pain caused the neuroplastic change which suppressed the neuronal pathway projecting from the brain region called bed nucleus of the stria terminalis (BNST) to the region called lateral hypothalamus (LH).

Using chemogenetics, an advanced technique to manipulate neuronal activity, they showed that restoration of the suppressed activity of this neuronal pathway attenuated the chronic pain-induced anxiety. These findings indicate that chronic pain-induced functional changes in the neuronal circuits within the BNST leads to maladaptive anxiety.

“These findings could not only lead to improved treatment of chronic pain, but also to new therapeutics for anxiety disorders,” says Minami.



Journal

Science Advances

DOI

10.1126/sciadv.abj5586

Method of Research

Experimental study

Subject of Research

Animals

Article Title

Chronic pain-induced neuronal plasticity in the bed nucleus of the stria terminalis causes maladaptive anxiety

Article Publication Date

27-Apr-2022

Tags: anxietychronicneuronalpaininducedplasticityrevealed
Share26Tweet16Share4ShareSendShare
  • IMAGE

    A new synthesis method for three-dimensional nanocarbons

    64 shares
    Share 26 Tweet 16
  • Within just a few months a deadly epidemic killed all the black sea urchins in the Gulf of Eilat – a great threat to the coral reef in Eilat

    68 shares
    Share 27 Tweet 17
  • How eating natto might help to distress

    64 shares
    Share 26 Tweet 16
  • GPS tracking reveals how a female baboon stopped using urban space after giving birth

    64 shares
    Share 26 Tweet 16
  • Promising building blocks for photonic quantum simulators

    64 shares
    Share 26 Tweet 16
  • Study highlights long-term benefits of family-based care following institutional care

    65 shares
    Share 26 Tweet 16
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

Society for Cardiovascular Angiography and Interventions bestows highest designation ranking to leading interventional cardiologists

SCAI announces new award recognizing the contributions of early career interventional cardiologists

Study finds cardiovascular risk score improves after one year of semaglutide use in patients with overweight and obesity

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 206 other subscribers

© 2023 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2023 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In