Nanograft seeded with 3 cell types promotes blood vessel formation to speed wound healing
New Rochelle, NY, April 26, 2016–Large or slow-healing wounds that do not receive adequate blood flow could benefit from a novel approach that combines a nanoscale graft onto which three different cell types are layered. Proper cell alignment on the nanograft allows for the formation of new blood vessel-like structures, as reported in of Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free for download on the Tissue Engineering website until May 26, 2016.
Tae Hee Kim, Soo Hyun Kim, PhD, Kam Leong, PhD, and Youngmee Jung, PhD, Korea Institute of Science and Technology, Korea University, Korea University of Science and Technology (Seoul, Korea) and Columbia University (New York, NY), describe the nanoscale topography and triculture technology they used to create a microenvironment that mimics what occurs in normal tissue and can promote angiogenesis. They demonstrate how the shape, width, and depth of the nanograft all affected the behavior of the cells and the formation of stable capillary-like tubular structures.
In the article "Nanografted Substrata and Triculture of Human Pericytes, Fibroblasts, and Endothelial Cells for Studying the Effects on Angiogenesis," the researchers describe how this technique could be applicable for treating wounds that do not heal well naturally.
"The combination of advanced materials and polycellular administration is opening new paths to the all-important requirement for angiogenesis in tissue engineering," says Co-Editor-in-Chief Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC.
About the Journal
Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-In-Chief Antonios Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed online at the Tissue Engineering website.
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News) was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.