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Home SCIENCE NEWS Cancer

MRI surveillance for postsurgical musculoskeletal soft-tissue sarcomas: AJR systematic review and meta-analysis

February 1, 2023
in Cancer
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Leesburg, VA, February 1, 2023—According to an accepted manuscript published in ARRS’ American Journal of Roentgenology (AJR), MRI-based surveillance after surgical treatment of musculoskeletal soft-tissue sarcomas (STS) shows utility for detecting clinically occult local recurrences (LRs), potentially improving patient outcomes.

PRISMA flow diagram shows identification, screening, and inclusion of studies

Credit: ARRS/AJR

Leesburg, VA, February 1, 2023—According to an accepted manuscript published in ARRS’ American Journal of Roentgenology (AJR), MRI-based surveillance after surgical treatment of musculoskeletal soft-tissue sarcomas (STS) shows utility for detecting clinically occult local recurrences (LRs), potentially improving patient outcomes.

“When used at a high intensity, MRI-based surveillance can detect many clinically occult LRs, although the studies are small, occasionally conflicting, and often of poor quality,” wrote corresponding author Natalia Gorelik, MD, from the department of diagnostic radiology at McGill University Health Center in Montreal, Quebec, Canada. “A survival benefit could be associated with imaging use, but further research is needed to evaluate the causality of any observed survival differences.”

In this AJR systematic review and meta-analysis, Gorelik et al. systematically searched multiple electronic databases through November 2022 for controlled trials and cohort studies on the usefulness of MRI-based surveillance for musculoskeletal STS. A total of 4,821 unique titles and abstracts were identified. After screening for eligibility and snowball sampling, 19 studies were included; all were retrospective cohorts.

Using an adapted Newcastle-Ottawa scale for assessing bias risk, random effects meta-analyses of the proportion of LRs discovered by MRI, as opposed to clinically, were conducted. The association of low- versus high-intensity surveillance—high intensity defined as at least one local surveillance imaging examination for low-risk tumors, as well as at least three for high-risk tumors during the first 2 posttreatment years—with the proportion of LR detected on MRI was assessed with a chi-square test of subgroup differences.

Ultimately, when MRI-based surveillance of musculoskeletal STSs was used at a high intensity, 53% (95% CI, 36–71%) of LRs were discovered with MRI. Four studies reported trends toward better survival for imaging-detected LRs or with more frequent imaging use.

“Although definite conclusions on the value of MRI-based surveillance are challenging to draw,” the authors of this AJR accepted manuscript acknowledged, “this study provides a comprehensive overview of the available evidence on the topic.”


North America’s first radiological society, the American Roentgen Ray Society (ARRS) remains dedicated to the advancement of medicine through the profession of medical imaging and its allied sciences. An international forum for progress in radiology since the discovery of the x-ray, ARRS maintains its mission of improving health through a community committed to advancing knowledge and skills with the world’s longest continuously published radiology journal—American Journal of Roentgenology—the ARRS Annual Meeting, InPractice magazine, topical symposia, myriad multimedia educational materials, as well as awarding scholarships via The Roentgen Fund®.



Journal

American Journal of Roentgenology

DOI

10.2214/AJR.22.28865

Method of Research

Systematic review

Subject of Research

People

Article Title

Usefulness of MRI-based local surveillance after surgical treatment of musculoskeletal soft-tissue sarcomas: A systematic review and meta-analysis

Article Publication Date

1-Feb-2023

COI Statement

This investigation was supported by an AUR GE Radiology Research Academic Fellowship Award and McGill Radiology Practice Plan funds received by Dr. Natalia Gorelik.
The other authors have no relevant disclosures.

Tags: AJRMetaanalysisMRImusculoskeletalpostsurgicalreviewsarcomassofttissuesurveillanceSystematic
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