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MPFI scientists probe function of cerebellar interneurons with new technique

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(Max Planck Florida Institute for Neuroscience) Researchers at the Max Planck Florida Institute for Neuroscience developed a technique for selectively targeting and controlling the interneurons of the cerebellar molecular layer relying on a genetically engineered mouse model that exploits a unique gene encoding c-Kit to differentiate interneurons from other cell types. By using the c-kit mice in this study, the team was able to specifically access molecular layer interneurons and manipulate their activity using both optogenetic and chemogenetic methods in vitro.

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