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Living liver donors satisfied with donation process says study

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A study of living liver donors found donors were highly satisfied with the donation process. Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases, indicate most donors would donate again, independent of any complications from transplantation.

Hepatitis viral infection, obesity, and alcohol abuse if not treated can lead to end-stage liver disease, which requires liver transplantation for survival. However, a shortage of deceased donor organs has contributed to a large number of patients on the waiting list. In fact, the Organ Procurement and Transplantation Network (OPTN) database reported that in 2012, there were 16,000 patients on the liver waiting list, 6,878 patients were transplanted, and 6,999 died while awaiting a liver. Of those transplanted that year, 96% received a deceased donor organ and only 4% were living donor transplants.

"Living liver donation is one of the most selfless acts a person can perform," said lead author Dr. Vanessa Humphreville with Case Western Reserve University Hospital in Cleveland, Ohio, and formerly with the Division of Transplantation, Department of Surgery, University of Minnesota where the study took place. "As transplant specialists it is our responsibility to educate donors about all aspects of the donation process and our study contributes to that knowledge by examining long-term quality of life."

For the present study researchers surveyed 127 living liver donors. The donor-specific survey that is used to determine living liver-donor morbidity was completed by 107 donors and the 36-item health survey assessed generic outcomes in 62 donors. The average follow-up period was roughly 7 years.

Results show that 11% of donors reported better health and 80% noted their health as the same as prior to donation, with 92% of living liver donors indicating they were employed. Incisional discomfort was the most common post-donation symptom noted by 34% of donors, while 22% of donors self-reported depressive symptoms following donation.

Further analyses show that increased vitality, decreased pain, and a recipient who was living were independently linked to donor satisfaction. "We found that living donors had above average quality of life compared to the general population with 97% of donors indicating they would donate again," comments Dr. Srinath Chinnakotla with Division of Transplantation, Department of Surgery at the University of Minnesota who supervised Dr. Humphreville's work on this study. "The findings show that living donation is a positive experience for donors and we must continue to share such information with potential liver donors."

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Full citation: "Long-Term Health-Related Quality of Life after Living Liver Donation." Vanessa R. Humphreville, David M. Radosevich, Abhinav Humar, William D. Payne, Raja Kandaswamy, John R. Lake, Arthur J. Matas, Timothy L. Pruett and Srinath Chinnakotla. Liver Transplantation; (DOI: 10.1002/lt.24304).

URL: http://doi.wiley.com/10.1022/lt.24304

Author Contact: Media wishing to speak with Drs. Chinnakotla or Humphreville may contact David Martinson with the University of Minnesota at [email protected]

About the Journal

Liver Transplantation is published by Wiley on behalf of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Since the first application of liver transplantation in a clinical situation was reported more than twenty years ago, there has been a great deal of growth in this field and more is anticipated. As an official publication of the AASLD and the ILTS, Liver Transplantation delivers current, peer-reviewed articles on surgical techniques, clinical investigations and drug research — the information necessary to keep abreast of this evolving specialty. For more information, please visit http://wileyonlinelibrary.com/journal/lt.

About Wiley

Wiley is a global provider of knowledge and knowledge-enabled services that improve outcomes in areas of research, professional practice and education. Through the Research segment, the Company provides digital and print scientific, technical, medical, and scholarly journals, reference works, books, database services, and advertising. The Professional Development segment provides digital and print books, online assessment and training services, and test prep and certification. In Education, Wiley provides education solutions including online program management services for higher education institutions and course management tools for instructors and students, as well as print and digital content. The Company's website can be accessed at http://www.wiley.com.

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