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Latin-Americans with different Native-American ancestry show different health risks

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Credit: Justo Lorenzo Bermejo and colleagues.

Latin Americans originate from a mix of people with Native American, European and African ancestry. A new study finds that different types of original Native American ancestry can be associated to different causes of death. Justo Lorenzo Bermejo and Felix Boekstegers from Heidelberg University in Germany, and their Chilean colleagues report these findings in a new study published May 26th, 2017 in PLOS Genetics.

Indigenous peoples in Latin America are genetically diverse. Genetic differences among Native Americans become obscured when researchers lump together the ancestry of all groups as "Native American" in biomedical studies. In the current study, researchers examined genetic data from 2,039 Chileans with mixed ancestry to investigate possible associations between top causes of death and the two major types of Native American ancestry in Chile, the Mapuche and the Aymara. They found and validated a link between Mapuche ancestry and gallbladder cancer, with each 1% increase in the Mapuche proportion representing a 3.7% increase in the risk of death from the disease. Mapuche ancestry was also associated with an increased risk of asthma, and with a decreased mortality by diabetes. Increasing proportions of Aymara ancestry were linked to greater risk of skin, bladder, larynx, bronchus and lung cancers.

The findings highlight the importance of taking into account the genetic contributions of different ancestral groups when researching ethnically diverse populations. Mapuche and Aymara ancestry show associations with different diseases, and grouping them together cancels out differences in risk. By separately considering genetic contributions from individual indigenous populations, scientists can better estimate a patient's risk and identify genetic variants underlying certain diseases.

Justo Lorenzo Bermejo adds: "The genome of Latin Americans is the result of a genetic mixture between Europeans, Africans and Native Americans from different indigenous peoples. The identification of health disparities among ethnic groups may have important implications for personalized prevention and disease management. This study demonstrates that considering the origin of the Native American component of ancestry can be crucial to identify existing associations with human disease. We plan to exploit this finding in future studies on Latin American health, in particular common cancers and infectious diseases in South America."

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In your coverage please use this URL to provide access to the freely available article in PLOS Genetics: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006756

Citation: Lorenzo Bermejo J, Boekstegers F, González Silos R, Marcelain K, Baez Benavides P, Barahona Ponce C, et al. (2017) Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile. PLoS Genet 13(5): e1006756. https://doi.org/10.1371/journal.pgen.1006756

Funding: This study was financially supported by the German Federal Ministry of Education and Research (BMBF, grant 01DN15021), Germany's Excellence Initiative of Heidelberg University within the program "Mobilitätsmaßnahmen im Rahmen internationaler Forschungskooperationen 2015-16", the support program "Stiftungen und Preise" of the Ruprecht-Karls-Universität Heidelberg, the Deutsche Forschungsgemeinschaft and the Ruprecht-Karls-Universität Heidelberg within the funding program Open Access Publishing, and the German Research Foundation (DFG, grant LO 2061/1). Sample collection and storage was supported by the Biobank of University of Chile. JSS is partially funded by USA NIH Grant GM053275. This work was partially supported by general funds from the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics (DCEG) and the Office of Research on Women's Health (ORWH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

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Justo Lorenzo Bermejo
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