Is use of prescription medications with depression as possible side effect common?

Bottom Line: More than one-third of U.S. adults may use prescription medications that have depression as a possible side effect.

Why The Research Is Interesting: Prescription medications are widely used among adults and many prescriptions, such as hormonal contraceptives and beta-blockers, are associated with increased risk of depression.

  <p><strong>Who and When</strong>: 26,192 adults who participated in a nationally representative survey between 2005-2014</p>    <p><strong>What (Study Measures)</strong>: Prescription medications with depression as a possible side effect (exposure); use of medications with potential to cause depression and depression (outcomes)</p>   <p><strong>How (Study Design)</strong>: This was a population-based survey study.</p>   <p><strong>Authors:</strong> Dima Mazen Qato, Pharm.D., M.P.H., Ph.D., University of Illinois at Chicago, College of Pharmacy, and coauthors</p>    <p><strong>Results:</strong> An estimated 37 percent of adults used prescription medications that had depression as a potential side effect; the use of multiple medications with depression as a possible side effect was associated with a greater likelihood of depression.</p>      <p><strong>Study Limitations:</strong> Cause-and-effect inferences cannot be made about the use of prescription medications and depressive symptoms; the survey cannot account for a history of depression</p>      <p><strong>Study Conclusions:</strong> Physicians should consider discussing associations between prescription medications and the likelihood of depression with patients who are prescribed medications with depression as a possible side effect.</p>     <p>###</p>      <p><strong>To Learn More:</strong> The full study is available on the For The Media website.</p>    <p>(doi:10.1001/jama.2018.6741)</p>     <p>Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.</p>        <strong>Want to embed a link to this report in your story? </strong>Link will be live at the embargo time:                                 <p><strong>Media Contact</strong></p>    <p>Jacqueline Carey  <br />[email protected]