Is risk for endocrine disease higher in survivors of cancer in adolescence, young adulthood?

Bottom Line: An increased risk of endocrine diseases, such as thyroid disease, testicular dysfunction and diabetes, was associated with people who survived cancer as adolescents and young adults.

Why The Research Is Interesting: Cancer survival rates have improved and it is necessary to explore the long-term consequences of cancer treatment.

  <p><strong>What and When</strong>: 32,548 one-year cancer survivors who were diagnosed at ages 15 to 39 and identified in the Danish Cancer Registry, along with 188,728 people who were cancer-free a nd identified through the Danish Civil Registration system; study conducted from 1976 to 2009 with follow-up from 1977 to 2010</p>   <p><strong>What (Study Measures and Outcomes)</strong>: First primary cancer diagnosed at ages 15 to 39 and treated according to recommendations and guidelines at the time of diagnosis (exposures); all hospital contacts (hospital admission and outpatient visits) for endocrine disease were identified in the National Patient Register and statistical estimates of hospitalization rates and risk were calculated</p>   <p><strong>How (Study Design)</strong>: This was an observational study. Researchers were not intervening for purposes of the study and cannot control for all the natural differences that could explain the study results.</p>    <p><strong>Authors:</strong> Mette Vestergaard Jensen, M.D., of the Danish Cancer Society Research Center, Copenhagen, Denmark, and coauthors</p>   <p><strong>Study Limitations:</strong> Lack of information on conditions diagnosed and treated by general practitioners; number of cases may be underestimated; cancer survivors more closely watched in the health care system and this could cause overestimation of risk estimates</p>   <p><strong>Related Material:</strong> The invited commentary, <strong>&quot;Unmet Survivorship Care Needs of Adolescent and Young Adult Cancer Survivors,&quot;</strong> by Stacey Marjerrison, M.D., M.Sc., F.R.C.P.C., of McMaster University, Ontario, Canada, also is available on the For The Media website.</p>   <p><strong>To Learn More:</strong> The full study is available on the For The Media website.</p>    <p>(doi:10.1001/jamanetworkopen.2018.0349)</p>      <p>Editor's Note: The article contains funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.</p>    <p>#  #  #</p>  <strong>Want to embed a link to this study in your story?: </strong>Links will be live at the embargo time    <p><strong>About JAMA Network Open:</strong> JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.  </p>    <p>###</p>                           <p><strong>Media Contact</strong></p>    <p>Mette Vestergaard Jensen  <br />[email protected]