Thursday, June 1, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Social & Behavioral Science

Indications of psychosis appear in cortical folding

April 25, 2018
in Social & Behavioral Science
0
Share on FacebookShare on Twitter
IMAGE

Credit: University Psychiatric Clinics Basel

Imaging techniques can be used to detect the development of psychosis in the brains of high-risk patients at an early stage, as reported by researchers from the University of Basel and Western University in the journal JAMA Psychiatry.

Detecting psychosis early increases the chances of effective treatment. Despite advances in diagnosis, however, it has previously not been possible to examine young people with initial psychotic symptoms and reliably say who will develop acute psychosis and who will not.

It has long been supposed that the condition is caused by disturbed communication between various groups of nerve cells. Modern imaging techniques have made it possible to make these connections between regions of the brain visible.

Researchers from the University of Basel have now examined the question of whether changes in the anatomical structure of brain networks can already be detected in people with an increased risk of psychosis. The study was carried out in collaboration with scientists from the Psychiatric University Clinics Basel, Western University and Lawson Health Research Institute in Ontario, Canada.

Focus on cortical folding

The researchers, led by Drs André Schmidt and Lena Palaniyappan, focused on cortical folding, known as gyrification: they examined how the folds in various regions of the brain interact with each other, and whether this interaction is impaired in high-risk patients.

They also tested how precisely they could use the cortical connectivity to predict which high-risk patients would suffer from psychosis and which would not.

Reduced interaction

For their study, the researchers examined 44 healthy control subjects, 38 patients with first-episode psychosis, and 79 people with an increased risk of psychosis, of which 16 later developed fully-formed psychosis. They reconstructed the brain's nerve pathways using magnetic resonance imaging and methods from mathematical graph theory, with which they described a network of nodes.

The results show that in comparison to the healthy control group, the folding in individual regions of the brain in patients with an initial psychotic episode and those with a later psychosis transition showed reduced integration and increased segregation.

The analysis also showed that this process enabled predictions to be made with more than 80% accuracy about which patients would later suffer from psychosis and which would not.

Biomarker for clinical diagnosis

"Our results indicate that this type of network analysis could significantly improve individual risk prognoses," says André Schmidt, who led the project. "Future longitudinal studies with larger samples are now needed to validate the prognostic accuracy of this measurement."

###

Media Contact

Cornelia Niggli
[email protected]
@UniBasel_en

http://www.unibas.ch/

Related Journal Article

http://dx.doi.org/10.1001/jamapsychiatry.2018.0391

Share25Tweet16Share4ShareSendShare
  • blank

    Why expensive wine appears to taste better

    71 shares
    Share 28 Tweet 18
  • Artificial intelligence system predicts consequences of gene modifications

    67 shares
    Share 27 Tweet 17
  • “You must have a preference”: How does lack of preference affect joint decision-making?

    67 shares
    Share 27 Tweet 17
  • Element creation in the lab deepens understanding of surface explosions on neutron stars

    75 shares
    Share 30 Tweet 19
  • Finally solved! The great mystery of quantized vortex motion

    64 shares
    Share 26 Tweet 16
  • Overfishing linked to rapid evolution of codfish

    64 shares
    Share 26 Tweet 16
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

Element creation in the lab deepens understanding of surface explosions on neutron stars

Why expensive wine appears to taste better

Study finds that eight factors put Black adults at greater risk of early death

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 206 other subscribers

© 2023 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2023 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In