In frogs, preventing early-life gut microbiome disruptions leads to better health

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Biologists at the University of Connecticut and University of South Florida have found that a crucial window in the development of tadpoles may influence a frog's ability to fight infectious diseases as an adult.

The scientists showed that an early-life disruption of the gut and skin bacterial communities of tadpoles later affects the adult frogs' ability to fight off parasitic gut worms.

The findings from a research team led by Sarah Knutie of UConn is published in the Nature Communications.

"Our study found that a disruption of bacteria in tadpoles has enduring negative effects on how adult frogs deal with their parasite," Knutie said. "These results suggest that preventing early-life disruptions of bacteria by factors such as nutrition, antibiotics and pollution, might confer protection against diseases later in life."

The project is significant not only for the insight it provides in threats to the health of the world's frogs, but in its potential applicability to understanding the immune systems of mammals and even humans.

The impact of a healthy bacterial community in the gut is an increasing focus of scientists looking to understand a wide-range of ailments in a many species, including humans. Previous research has found that an early-life disruption of the gut microbiota mammals can result in a hyper-reactive immune system that may increase the subsequent risk of immune-related health issues, such as allergies and autoimmune diseases.

In their experiments, the scientific team manipulated the bacterial communities of Cuban tree frog tadpoles and then exposed them to parasites later in life. The tadpoles were either raised in natural pond water or one of three other treatments to manipulate the bacterial communities: sterile pond water, sterile pond water with short-term antibiotics, or sterile pond water with long-term antibiotics.

Adult frogs that had reduced bacterial diversity as tadpoles had three times more parasites than adults that did not have their microbiota disrupted as tadpoles, the study said. Those results suggest that preventing early-life disruptions of host-associated bacterial communities might reduce infection risk later in life, the researchers wrote.

"We think that the microbiota of juveniles likely played a role in priming the immune system against parasite establishment," the researchers wrote. "We found that the relative abundance of certain bacteria … in juveniles was positively correlated with parasite resistance in adulthood." Knutie began the research as a post-Doctoral researcher at the University of South Florida and was recently appointed to the UConn faculty.

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The project was funded by the National Science Foundation, the British Ecological Society, the National Institutes of Health, the U.S. Department of Agriculture and the Environmental Protection Agency.

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http://dx.doi.org/10.1038/s41467-017-00119-0

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