Huge genetic diversity among Papuan New Guinean peoples revealed
The first large-scale genetic study of people in Papua New Guinea has shown that different groups within the country are genetically highly different from each other. Scientists at the Wellcome Trust Sanger Institute and their colleagues at the University of Oxford and the Papua New Guinea Institute of Medical Research reveal that the people there have remained genetically independent from Europe and Asia for most of the last 50,000 years, and that people from the country's isolated highlands region have been completely independent even until the present day.
Reported today (15 September) in Science, the study also gives insights into how the development of agriculture and cultural events such as the Bronze or Iron Age could affect the genetic structure of human societies.
Papua New Guinea is a country in the southwestern Pacific with some of the earliest archaeological evidence of human existence outside Africa. Largely free from Western influence and with fascinating cultural diversity, it has been of enormous interest to anthropologists and other scientists seeking to understand human cultures and evolution.
With approximately 850 domestic languages, which account for over 10 per cent of the world's total, Papua New Guinea is the most linguistically diverse country in the world. To discover if the linguistic and cultural diversity was echoed in the genetic structure of the population, researchers studied the genomes of 381 Papuan New Guinean people from 85 different language groups within the country.
The researchers looked at more than a million genetic positions in the genome of each individual, and compared them to investigate genetic similarities and differences. They found that groups of people speaking different languages were surprisingly genetically distinct from each other.
Anders Bergström, the first author on the paper from the Wellcome Trust Sanger Institute, said: "This is the first large-scale study of genetic diversity and population history in Papua New Guinea. Our study revealed that the genetic differences between groups of people there are generally very strong, often much stronger even than between major populations within all of Europe or all of East Asia."
Professor Stephen J. Oppenheimer, second author of the paper from the Wellcome Trust Centre for Human Genetics, University of Oxford, said: "We found a striking difference between the groups of people who live in the mountainous highlands and those in the lowlands, with genetic separation dating back 10,000-20,000 years between the two. This makes sense culturally, as the highland groups historically have kept to themselves, but such a strong genetic barrier between otherwise geographically close groups is still very unusual and fascinating."
Human evolution in Europe and Asia has been greatly influenced by the development of agriculture around 10,000 years ago. When small bands of hunter-gatherers settled into villages and started farming, they expanded and over time gave rise to more genetically homogenous (similar) societies. However, despite the independent development of agriculture in Papua New Guinea at about the same time, the same process of homogenization did not occur here. This may indicate that other historical processes in Europe and Asia, such as the later Bronze and Iron Ages, were the key events that shaped the current genetic structure of those populations.
Dr Chris Tyler-Smith, corresponding author on the paper from the Wellcome Trust Sanger Institute, said: "Using genetics, we were able to see that people on the island of New Guinea evolved independently from rest of the world for much of the last 50,000 years. This study allows us to glimpse a different version of human evolution from that in Europe and Asia, one in which there was agriculture but no later Bronze Age or Iron Age. Papua New Guinea might show the genetic, cultural and linguistic diversity that many settled human societies would have had before these technological transformations."
Notes to editors:
- Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
- School of Anthropology and Museum Ethnography, University of Oxford, Oxford OX2 6PE, UK.
- Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
- Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
- Biological Anthropology, Department of Archaeology and Anthropology, University of Cambridge, Cambridge CB2 1QH, UK.
- School of Archaeology and Anthropology, Australian National University, Canberra, ACT 2601, Australia.
- International Health Research, Curtin University, Perth, WA 6845, Australia.
- Papua New Guinea Institute of Medical Research, Post Office Box 60, Goroka, Papua New Guinea.
The Wellcome Trust Centre for Human Genetics
The Wellcome Trust Centre for Human Genetics is a research institute of the Nuffield Department of Medicine at the University of Oxford, funded by the University, the Wellcome Trust and numerous other sponsors. It is based in purpose-built laboratories on the University of Oxford's Biomedical Research Campus in Headington, one of the largest concentrations of biomedical expertise in the world, with more than 400 active researchers. http://www.well.ox.ac.uk/home
The Papua New Guinea Institute of Medical Research
The Papua New Guinea Institute of Medical Research (PNGIMR) was established in 1968 in Eastern Highlands Province and today is recognised as a prestigious biomedical and social sciences research institution in Papua New Guinea and globally. The PNGIMR is a statutory institution of the PNG Government and is tasked with conducting research into health problems with the ultimate goal of providing effective interventions which will lead to improvements in health and in the control and prevention of diseases.
The Wellcome Trust Sanger Institute
The Wellcome Trust Sanger Institute is one of the world's leading genome centres. Through its ability to conduct research at scale, it is able to engage in bold and long-term exploratory projects that are designed to influence and empower medical science globally. Institute research findings, generated through its own research programmes and through its leading role in international consortia, are being used to develop new diagnostics and treatments for human disease. http://www.sanger.ac.uk
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