Genome structure of dinosaurs discovered by bird-turtle comparisons
A discovery by scientists at the University of Kent has provided significant insight into the overall genome structure of dinosaurs.
By comparing the genomes of different species, chiefly birds and turtles, the Kent team were able to determine how the overall genome structure (i.e. the chromosomes) of many people's favourite dinosaur species – like Velociraptor or Tyrannosaurus – might have looked through a microscope.
The research was carried out in the laboratory of Professor Darren Griffin, of the University's School of Biosciences, and is now published in the journal Nature Communications. It involved extrapolating the likely genome structure of a shared common ancestor of birds and turtles that lived around 260 million years ago – 20 million years before the dinosaurs first emerged.
Dr Becky O'Connor, senior postdoctoral researcher and co-author of the Nature Communications paper, then traced how chromosomes changed over evolutionary time from a reptile ancestor to the present day.
The team found that, although the individual chromosomes rearranged their genes internally, this did not occur much at all between the chromosomes – what the scientists describe as 'a significant discovery'.
Birds (which are themselves living dinosaurs) have a lot of chromosomes compared to most other species and that is possibly one of the reasons why they are so diverse. This research suggests that the pattern of chromosomes (karyotype) seen in early emerging dinosaurs and later theropods is similar to that of most birds and, again, may help explain their great diversity.
The new discovery suggests that, had scientists had the opportunity to make a chromosome preparation from a theropod dinosaur, it might have looked very similar to that of a modern-day ostrich, duck or chicken.
One of the key pieces of biotechnology that made it possible was the development of a set of fluorescent probes derived from birds that worked well on the chromosomes of turtles.
The genetics laboratory run by Professor Darren Griffin in Kent's School of Biosciences carries out research into how genes organise into chromosomes and how that is different between species. The work is a collaboration with Dr Denis Larkin at the Royal Veterinary College in London, Iowa State University, the University of Cambridge, Oxford Genome Technologies and the Natural History Museum, London. The work is a collaboration with Dr Denis Larkin at the Royal Veterinary College in London, Iowa State University, the University of Cambridge, the Cambridge company Cytocell and the Natural History Museum, London.
Reconstruction of genome organization in the diapsid common ancestor permits tracing of chromosome evolution in avian and non-avian dinosaurs is published in Nature Communications doi: 10.1038/s41467-018-04267-9
Authors: Rebecca E. O'Connor1, Michael N. Romanov1, Lucas G. Kiazim1, Paul M. Barrett2, Marta Farré3, Joana Damas3, Malcolm Ferguson-Smith4, Nicole Valenzuela5, Denis M. Larkin3*, Darren K. Griffin1*.
1 School of Biosciences, University of Kent, Canterbury, Kent CT5 7NJ, UK
2 Department of Earth Sciences, Natural History Museum, Cromwell Road, London SW7 5BD, UK
3 Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London NW1 0TU, UK
4 Department of Veterinary Medicine, Cambridge University, Cambridge CB3 0ES, UK 5 Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Iowa 50011, USA
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Notes to Editors
Making chromosome preparations is commonplace in humans to diagnose conditions like Down Syndrome, diseases like cancer, or to establish the reasons for pregnancy loss. It also can be used to examine processes of genome evolution in living and extinct animals.
When doing the same in other animals (e.g. pigs) infertility can be diagnosed or varying patterns between species can be spotted. The Kent team provide a service to the pig breeding industry to do this.
Kent Screening Lab details: For all details of cytogenetic screening services of animals including pigs and cattle contact Dr Rebecca O'Connor R.O'Connor@kent.ac.uk
The University of Kent, led by the School of Biosciences will be launching the Institute for Biotechnology and Molecular Medicine (iBaMM). The stated aims of iBaMM are to study normal biological processes, their relevance to health and apply molecular biotechnology to benefit mankind providing a focus for catalyzing new biological discoveries that that take basic research through to application. iBaMM will be a hub of impact-generating activity, developing intellectual property, public and societal engagement and new products and processes of relevance to industry and medical practice.
Established in 1965, the University of Kent – the UK's European university – now has almost 20,000 students across campuses or study centres at Canterbury, Medway, Tonbridge, Brussels, Paris, Athens and Rome.
It has been ranked 22nd in the Guardian University Guide 2018 and 25th in the Complete University Guide 2018, and in June 2017 was awarded a gold rating, the highest, in the UK Government's Teaching Excellence Framework (TEF).
In the Times Higher Education (THE) World University Rankings 2015-16, it is in the top 10% of the world's leading universities for international outlook and 66th in its table of the most international universities in the world. The THE also ranked the University as 20th in its 'Table of Tables' 2016.
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<h4>Related Journal Article</h4>http://dx.doi.org/10.1038/s41467-018-04267-9