Around 3,000 heroin addicts currently receive opioids such as methadone, buprenorphine or morphine as part of their treatment in the Canton of Zurich. The number of these so-called substitution treatments has remained constant since their introduction in the 1990s. Long-term courses of therapy with methadone or other opioids evidently reduce the consumption of illegal drugs among patients addicted to heroin. Although the beginning of this kind of treatment also leads to a reduction in the consumption of alcohol, more patients drink alcohol more frequently today than in previous decades. This is shown in a new long-term study conducted by researchers from the University Psychiatric Hospital and the University of Zurich.
Heroin and cocaine consumption markedly reduced
The study includes data on nearly 9,000 patients with a heroin addiction who underwent substitution therapy in the Canton of Zurich between 1998 and 2014. They already consumed sustainably less heroin or cocaine – and somewhat less alcohol – from the beginning of the treatment. Moreover, the proportion of patients who consumed heroin frequently (at least five days per week) more than halved over the 17-year study period (from 14.4 to six percent), and the number of frequent cocaine consumers shrank from 8.5 to 4.9 percent. The results also demonstrate that the decrease in heroin consumption went hand in hand with an improved social situation for the patients.
Nearly one in four frequently consumes alcohol
"Alcohol consumption, on the other hand," explains Marcus Herdener, study head and chief physician at the University Psychiatric Hospital, "increased during the study period." Towards the end of the study, almost one in four patients (22.5%) frequently consumed alcohol. "It seems to mirror a general trend that this patient group drinks more alcohol," says Herdener. As liver infections such as hepatitis B and C are also commonplace among people with opioid addiction, frequent alcohol consumption seriously jeopardizes the health of these ageing patients.
According to other studies, an increasing number of opioid-dependent people die from liver disease. The results of the Zurich study are significant: "They reveal that there is still a major therapeutic need for treatment with regard to frequent alcohol consumption," Herdener concludes.
Marcus Herdener, Kenneth M. Du?rsteler, Erich Seifritz, and Carlos Nordt. Changes in substance use in patients receiving opioid substitution therapy and resulting clinical challenges: a 17-year treatment case register analysis. Lancet Psychiatry. February 28, 2017. DOI: 10.1016/S2215-0366(17)30080-9
PD Dr. med. Marcus Herdener
Head of the Center for Addictive Disorders
University Psychiatric Hospital Zurich
University of Zurich
Phone: +41 44 205 58 10
University of Zurich
Phone: +41 44 634 44 67
Dr. Marcus Herdener