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Fat tissue may impede radiotherapy for breast cancer patients

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According to research published online in The FASEB Journal, repeated irradiation of breast fat (also known as adipose tissue) produces an inflammatory response that ultimately reduces the efficiency of radiotherapy in breast cancer patients. This research was based on a recent discovery that there is an inflammatory interaction between breast tumors and adipose tissue.

"Patients often undergo 25 daily doses of radiotherapy to the whole breast after surgical removal of the tumor to ensure that any remaining breast cancer cells are destroyed," said David N. Brindley, Ph.D., D.Sc., professor at the Heritage Medical Research Centre within the Department of Biochemistry at Canada's University of Alberta. "During this treatment, the adipose tissue releases autotaxin, an enzyme that initiates a wound healing response. This response ends up protecting the remaining cancer cells and allowing tumors to establish themselves and avoid destruction."

To test this idea, Brindley and colleagues exposed rat and human adipose tissue to radiation doses expected during radiotherapy. The radiation produced an increase in autotaxin and an inflammatory wound healing response. The researchers identified several agents that could be used to block inflammation and decrease the wound healing response, which they expect would improve the effectiveness of the radiotherapy.

"This is a potentially major discovery in relation to the efficacy of breast cancer radiation therapy" said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal.

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Submit to The FASEB Journal by visiting http://fasebj.msubmit.net, and receive monthly highlights by signing up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is the world's most cited biology journal according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

FASEB is composed of 30 societies with more than 125,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

Details: Guanmin Meng, Xiaoyun Tang, Zelei Yang, Matthew G. K. Benesch, Alison Marshall, David Murray, Denise G. Hemmings, Frank Wuest, Todd P. W. McMullen, and David N. Brindley. Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy. FASEB J. doi:10.1096/fj.201700159R ; http://www.fasebj.org/content/early/2017/05/24/fj.201700159R.abstract

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http://dx.doi.org/10.1096/fj.201700159R

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