FASEB Science Research Conference: Reversible Acetylation on Health and Disease
Over the past few years, the "epigenetic" regulation of the genome has become increasingly important to understanding both the etiology and fundamental mechanisms of aging and age-related diseases. Key to epigenetic regulation are two classes of lysine-modifying enzymes, the histone deacetylases (sirtuins and HDACs) and the histone acetyltransferases (HATs).
This SRC is the only conference dedicated to protein acetylation, and will bring together leaders in the field to exchange exciting new fundamental discoveries such as new lysine post-translational modifications (e.g. 3-hydroxybutyryl lysine and palmitoyl lysine) and the how these modifications can regulate transcription, cell signaling, and protein secretion.
A primary objective of the conference is to transfer knowledge and foster collaboration between basic academic researchers, clinical scientists, and industrial researchers to understand how lysine acetylation controls human health and how to prevent and treat a diverse set of age-related diseases that could extend human healthspan and lifespan. A second objective is to foster the development and interests of younger investigators to help support their career development. This meeting is particularly timely because recent development on bromodomain inhibitors is continuing to generate a lot of interests and more clinical data on small molecule modulators of sirtuins and HDACs are being generated.