Bethesda, MD – This SRC is the third international retinoid conference. With the discovery of the nuclear retinoid receptors, retinoic acid receptors (RARs) and retinoid X receptors (RXRs), the retinoid field has been implicated in new areas of scientific inquiry including metabolism, metabolic diseases, and neurobiology. The demonstration that RXRs serve as master regulators and signal integrators facilitated transcriptional crosstalk with retinoids and other nuclear receptor superfamily members has broadened interest in retinoid biology and pharmacology. Efforts to study retinoid down-stream signaling effects accelerated discoveries made beyond the nuclear receptors themselves.
Progress has been made in identifying, cloning, and analyzing a family of enzymes critical for the synthesis and degradation of retinoids. Many proteins involved in regulation of retinoid metabolism, homeostasis, and signaling pathways are being explored as potential therapeutic and preventive targets. While retinoid toxicities have limited their application in the clinic, the recent discovery of retinoid receptor selective agonists and antagonists and of multiple novel non-genomic retinoid signaling pathways provided ample opportunities to refine retinoid chemistry and to broaden clinical applications. Receptorselective retinoids retain desired pharmacologic activities, but have reduced toxicities. Exciting examples are the of rexinoids to treat Alzheimer's disease and the physiologic morphogen for T regulatory cells. Timely communication of cutting-edge insights in this field is needed to advance retinoid basic science and biology and to realize public health benefits from this.
FASEB has announced a total of 36 Science Research Conferences (SRC) in 2016. Registration opens January 7, 2016. For more information about an SRC, view preliminary programs, or find a listing of all our 2016 SRCs, please visit http://www.faseb.org/SRC.
Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes. In efforts to expand the SRC series, potential organizers are encouraged to contact SRC staff at [email protected] Proposal guidelines can be found at http://www.faseb.org/SRC.
FASEB is composed of 30 societies with more than 125,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.