Thursday, August 11, 2022
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Chemistry AND Physics

Even after anti-androgen therapy, docetaxel remains useful in prostate cancer

January 11, 2016
in Chemistry AND Physics
0
Share on FacebookShare on Twitter

IMAGE

IMAGE: Thomas W. Flaig, MD, and colleagues show benefit of docetaxel after targeted anti-androgen therapy abiraterone.

Credit: University of Colorado Cancer Center

A study presented at the 2016 Genitourinary Cancers Symposium shows that 40 percent of patients with castration-resistant metastatic prostate cancer (mCRPC) treated with docetaxel following abiraterone had at least 50 percent reduction in prostate specific antigen (PSA), demonstrating the activity of this drug sequencing.

"The chemotherapy docetaxel used to be our first-line therapy for mCRPC. Now we use androgen receptor targeted therapy first. The question was whether docetaxel still has a role in these patients treated with abiraterone. We're no longer using docetaxel first – should we even be using it second?" says Thomas W. Flaig, MD, associate director for clinical research at the University of Colorado Cancer Center, associate professor of medicine at the University of Colorado School of Medicine, and one of the study's principal investigators.

The multi-institution study followed 1088 patients treated on the clinical trial COU-AA-302, which provided the data that led to the approval of abiraterone as a first-line therapy.

"Basically, we wanted to know how these patients were treated after the trial," Flaig says.

Sixty-seven percent of the patients treated with abiraterone went on to receive further therapies, with 36 percent receiving two additional therapies and 17 percent receiving three or more. About half of all Abiraterone-treated patients on the study were treated with docetaxel in the next subsequent line of therapy. Of these patients treated with docetaxel immediately after abiraterone, 40 percent had PSA decline by more than half, demonstrating the effectiveness of this chemotherapy even after treatment with androgen-deprivation therapy.

"Surprisingly, the next most common "treatment" in this setting after doecetaxel was no treatment at all," Flaig says.

Compared with younger patients, patients older than 75 years were about twice as likely to receive no subsequent therapy. Flaig notes that the trial itself ended in 2010, before the approval of the drug enzalutamide which is also used as a pre-chemotherapy treatment for mCRPC, likely meaning that more patients of all ages are now receiving additional anti-androgren therapy prior to the use of chemotherapies including docetaxel.

"This confirms the activity of abiraterone followed by docetaxel and represents important data on the sequencing of medical therapies under this new paradigm," Flaig says. "The fact that a substantial portion of patients received no subsequent therapy after the study was done, needs additional study to be certain we are maximizing effective therapy for these patients."

###

Media Contact

Garth Sundem
[email protected]
@CUAnschutz

http://www.ucdenver.edu

Share25Tweet16Share4ShareSendShare
  • Quaise_Energy_Gyrotron.png

    Experts optimistic about converting coal plants to production of clean geothermal energy

    113 shares
    Share 45 Tweet 28
  • U.S. Department of Energy selects Los Alamos National Lab to lead $9.25 million advanced computing partnership

    70 shares
    Share 28 Tweet 18
  • Surprise, surprise: Subsurface water on Mars defy expectations

    66 shares
    Share 26 Tweet 17
  • Study links protecting Indigenous peoples’ lands to greater nonhuman primate biodiversity

    65 shares
    Share 26 Tweet 16
  • Reinvigorating ‘lost cause’ exhausted T cells could improve cancer immunotherapy

    66 shares
    Share 26 Tweet 17
  • U-M study: Local renewable energy employment can fully replace U.S. coal jobs nationwide

    65 shares
    Share 26 Tweet 16
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

Experts optimistic about converting coal plants to production of clean geothermal energy

A role for cell ‘antennae’ in managing dopamine signals in the brain

The walk of Japanese children develops differently from children in other countries

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 193 other subscribers

© 2022 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2022 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In