A groundbreaking multiomics study has unraveled the intricate epigenetic and transcriptional landscapes of acute myeloid leukemia (AML) at single-cell resolution, offering unprecedented insights into disease heterogeneity and lineage-specific regulatory mechanisms. Researchers analysed over 280,000 mononuclear cells from 36 AML patient samples across 16 ATAC-defined subgroups alongside remission controls, integrating single-cell RNA sequencing (scRNA-seq) and assay … Continue reading Epigenetic Variation Shapes Chromatin in Acute Myeloid Leukemia