Effects of a major drug target regulated through molecular ‘codes’

(Van Andel Research Institute) The findings, published today in Cell, reveal for the first time components of a G protein-coupled receptor (GPCR) named rhodopsin bound to a signaling molecule called arrestin, both crucial pieces of the body's intricate cellular communication network. The new discovery further refines a landmark 2015 Nature article that first described the structure of the two molecules in complex together.