Effect of twice-weekly calorie restriction diet for glycemic control in patients with type 2 diabetes

Bottom Line: A diet with calorie restriction two days per week was comparable to a diet with daily calorie restriction for glycemic control in patients with type 2 diabetes.

Why The Research Is Interesting: Conventional weight-loss diets with daily calorie restriction are hard to stick with over time. Intermittent calorie restriction diets can be effective for weight loss. This study examined the long-term effects of a two-day intermittent calorie restriction diet with a diet of continuous calorie restriction over 12 months for patients with type 2 diabetes.

What and When: 137 patients with type 2 diabetes were assigned to 1 of 2 diets between April 2015 and September 2017

What (Study Interventions and Outcomes): 70 patients assigned to an intermittent calorie restriction diet (500-600 calories/day) on two nonconsecutive days with their regular diet the other five days per week and 67 patients assigned to a daily calorie restriction diet (1,200-1,500 calories/day) for 12 months (interventions); change in hemoglobin A1c (primary outcome)

How (Study Design): This was a randomized noninferiority trial. This type of randomized clinical trial is designed to assess whether an intervention is "no worse" than the comparison intervention.

Authors: Peter M. Clifton, M.D., Ph.D., of the University of South Australia, Adelaide, and coauthors

Results: The average change in hemoglobin A1c after a year was comparable between the two diets.

Study Limitations: The study population had well-controlled type 2 diabetes; medication adjustments can complicate interpreting changes in hemoglobin A1c levels; and study participants had more contact with a dietitian than is usual in a clinical setting

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To Learn More: The full study is available on the For The Media website.

(doi:10.1001/jamanetworkopen.2018.0756)

Editor's Note: The article contains funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Want to embed a link to this study in your story?: Links will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2018.0756

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

Media Contact

Media Contact

Peter M. Clifton, M.D., Ph.D.
[email protected]

@ JAMANetworkOpen

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