Effect of fluvoxamine vs placebo on clinical deterioration in outpatients with symptomatic COVID-19

What The Study Did: This randomized trial compares the effects of fluvoxamine, a selective serotonin reuptake inhibitor with immunomodulatory effects, versus placebo on a composite of dyspnea or pneumonia and oxygen desaturation among adult outpatients with polymerase chain reaction-confirmed mild COVID-19 illness.

Authors: Eric J. Lenze, M.D., of the Washington University School of Medicine in St. Louis, is the corresponding author.

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(doi:10.1001/jama.2020.22760)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Media advisory: The full study and editorial are linked to this news release.

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