Drug could cut transplant rejection
A diabetes drug currently undergoing development could be repurposed to help end transplant rejection, without the side-effects of current immunosuppressive drugs, according to new research by Queen Mary University of London (QMUL).
In the study, funded by the British Heart Foundation (BHF) and published in Immunity, researchers found that the enzyme glucokinase increases the movement of a type of T cell, called a regulatory T cell, into human organs. Once inside the organ tissue these regulatory T cells act as guardians of the immune system, preventing it from rejecting a transplanted organ.
The researchers found that when regulatory T cells were treated with a drug known to increase the activity of the glucokinase enzyme they moved into the organ tissue of mice in much greater numbers.
The team then studied blood samples from a group of people who have a genetic mutation making their version of the glucokinase enzyme more active. They found that in these people, the regulatory T cells move into the organs more readily.
These results suggest that a drug currently being developed to treat people with type 2 diabetes which increases the activity of the glucokinase enzyme could now also be used to prevent organ rejection after a transplant.
Currently, drugs used to prevent organ rejection have a number of side effects, including leaving patients at greater risk of infections and also cancer, because they are unable to specifically target the area of the immune system responsible for organ rejection.
BHF Professor Federica Marelli-Berg, Professor of Cardiovascular Immunology at QMUL, who led the research, said: "With this research we've hit upon a completely different way to stop organ rejection.
"Our next step is to take the drug into clinical trials. If the trials are successful, these findings could prove to be life-changing for patients who have had a transplant."
Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, which funded the research, said: "Heart transplantation has come a long way since the first heart transplant nearly fifty years ago. However, when our immune system rejects the donated heart this can have devastating consequences.
"With this research we are one step closer to reducing the number of people suffering from organ rejection, and to prevent people from re-joining a growing transplant waiting list.
"Ultimately, allowing people who have undergone this procedure to live longer, healthier lives with a healthy donor heart."
About the British Heart Foundation (BHF)
For over 50 years we've pioneered research that's transformed the lives of people living with heart and circulatory conditions. Our work has been central to the discoveries of vital treatments that are changing the fight against heart disease. But so many people still need our help. From babies born with life-threatening heart problems to the many Mums, Dads and Grandparents who survive a heart attack and endure the daily battles of heart failure. Every pound raised, minute of your time and donation to our shops will help make a difference to people's lives. For more information, visit bhf.org.uk
About Queen Mary University of London (QMUL)
Queen Mary University of London (QMUL) is one of the UK's leading universities with 23,120 students representing more than 160 nationalities.
A member of the Russell Group, we work across the humanities and social sciences, medicine and dentistry, and science and engineering, with inspirational teaching directly informed by our research. In the most recent national assessment of the quality of research, we were placed ninth in the UK amongst multi-faculty universities (Research Excellence Framework 2014).
As well as our main site at Mile End – which is home to one of the largest self-contained residential campuses in London – we have campuses at Whitechapel, Charterhouse Square, and West Smithfield dedicated to the study of medicine and dentistry, and a base for legal studies at Lincoln's Inn Fields.
Queen Mary began life as the People's Palace, a Victorian philanthropic project designed to bring culture, recreation and education to the people of the East End. We also have roots in Westfield College, one of the first colleges to provide higher education to women; St Bartholomew's Hospital, one of the first public hospitals in Europe; and The London, one of England's first medical schools.
Today, as well as retaining these close connections to our local community, we are known for our international collaborations in both teaching and research.