Tuesday, July 5, 2022
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Medicine & Health

Differences in B cell responses to coronaviruses and other pathogens in children and adults

April 12, 2021
in Medicine & Health
0
Share on FacebookShare on Twitter

Blood taken from a small group of children before the COVID-19 pandemic contains memory B cells that bind SARS-CoV-2 and weakly cross-react with other coronaviruses, a new study finds, while adult blood and tissue showed few such cells. “Further study of the role of cross-reactive memory B cell populations… will be important for ongoing improvement of vaccines to SARS-CoV-2, its viral variants, and other pathogens,” the authors say. As the COVID-19 pandemic has continued, children have often exhibited faster viral clearance and lower viral antigen loads than adults; whether B cell repertoires against SARS-CoV-2 (and other pathogens) differ between children and adults, contributing to differential responses, remains unknown. More broadly, it is still unclear how B cell memory to different antigens distributes in human tissues and changes during an individual’s lifespan. To study this, Fan Yang et al. analyzed blood samples taken from pre-pandemic children and pre-pandemic adults. They also studied blood and tissue samples from deceased organ donors. The authors analyzed B cell receptor (BCR) repertoires – which reveal the antigen a B cell targets – specific to six common pathogens as well as two viruses the participants had not encountered before: Ebola virus and SARS-CoV-2. In comparison to adults, pre-pandemic children not only had higher frequencies of convergent (shared) B cell clones in their blood for pathogens they have encountered, but also higher frequencies of class-switched convergent B cell clones against SARS-CoV-2 and its viral variants. Adult blood and tissues showed few such clones. Notably, neither children nor adults had many BCRs for Ebola virus, highlighting the contrast to SARS-CoV-2 and other human coronaviruses commonly encountered prior to the current pandemic. “We hypothesize that previous [coronavirus] exposures may stimulate cross-reactive memory, and that such clonal responses may have their highest frequencies in childhood,” the authors say. The results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.

###

Media Contact
Press Package Team
[email protected]
http://dx.doi.org/10.1126/science.abf6648

Tags: Medicine/Health
Share25Tweet16Share4ShareSendShare
  • The COVID virus invading a cell

    COVID-19 fattens up our body’s cells to fuel its viral takeover

    97 shares
    Share 39 Tweet 24
  • Alcohol changes brain activity differently in male and female mice

    66 shares
    Share 26 Tweet 17
  • Scientists discover key to hepatitis A virus replication, show drug effectiveness

    65 shares
    Share 26 Tweet 16
  • New imaging technology less accurate than MRI at detecting prostate cancer, trial shows

    66 shares
    Share 26 Tweet 17
  • These energy-packed batteries work well in extreme cold and heat

    65 shares
    Share 26 Tweet 16
  • Neighborhood ‘redlining’ associated with increased risk of heart disease

    65 shares
    Share 26 Tweet 16
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

nTIDE May 2022 COVID Update: Uncertainty about inflation tempers good news for people with disabilities

COVID-19 fattens up our body’s cells to fuel its viral takeover

The pair of Orcas deterring Great White Sharks – by ripping open their torsos for livers

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 190 other subscribers

© 2022 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2022 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
Posting....