More than 500,000 people in the United States undergo rehabilitation following a stroke or brain injury every year. Movement impairments following a stroke are a major cause of adult disability in the United States, and routine treatments are not currently optimized for individual patient needs.
Credit: Image provided by the University of Oklahoma.
More than 500,000 people in the United States undergo rehabilitation following a stroke or brain injury every year. Movement impairments following a stroke are a major cause of adult disability in the United States, and routine treatments are not currently optimized for individual patient needs.
University of Oklahoma biomedical engineer Yuan Yang, Ph.D., has received a Faculty Early Career Development Award, known as a CAREER award, from the National Science Foundation to advance the scientific study of brain functional changes after a stroke and pioneer a tailored rehabilitation strategy that fits individual needs.
“The way a stroke victim’s brain adapts to the injury varies from individual to individual,” Yang said. “But routine clinical practice tends to treat everyone the same. When that happens, doctors cannot provide an optimal treatment for each patient.”
Yang is an OU-Tulsa assistant professor in the Stephenson School of Biomedical Engineering, Gallogly College of Engineering. He will use multi-modal MRI scans in combination with an electrical neural activity scan to precisely assess the changes to motor control in an injured brain.
“Despite numerous efforts to develop new technologies for movement rehabilitation after a stroke, optimal recovery is still limited due to a lack of imaging guidance and real-time neurofeedback to tailor a rehabilitation strategy for each individual,” Yang said. “Our program will be able to tell doctors which areas of the brain to stimulate in a non-invasive, non-painful manner to reduce a patient’s recovery time and reduce the health care and nursing costs for long-term disability caused by stroke and other similar brain injuries.”
The five-year award will also support the development of a multidisciplinary research education ecosystem to connect engineering students, clinician trainees and STEM educators.
“OU Norman’s biomedical engineering program is excellent and so is the clinical program on the OU Health Sciences Center campus. Thanks to this grant, engineering students and medical students can collaborate during summer research trainings so that each can appreciate the other’s expertise,” Yang said. “We will also invite high school STEM teachers to join the training and take custom projects back to their classrooms.”
A collaboration with Science Museum Oklahoma will provide resources on brain science, including the development and donation of posters, toy models and exhibits to “excite and inspire young kids about science, medicine and the brain,” Yang said.
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About the Project
This project, “CAREER: Neuro-navigation guided non-invasive brain stimulation for individualized precision rehabilitation in stroke,” is jointly funded by the Disability and Rehabilitation Engineering Program and the Established Program to Stimulate Competitive Research (EPSCoR), award no. 2236459. The project begins April 1, 2023, and is expected to conclude March 31, 2028.
About the University of Oklahoma Office of the Vice President for Research and Partnerships
The University of Oklahoma is a leading research university classified by the Carnegie Foundation in the highest tier of research universities in the nation. Faculty, staff and students at OU are tackling global challenges and accelerating the delivery of practical solutions that impact society in direct and tangible ways through research and creative activities. OU researchers expand foundational knowledge while moving beyond traditional academic boundaries, collaborating across disciplines and globally with other research institutions as well as decision makers and practitioners from industry, government and civil society to create and apply solutions for a better world. Find out more at ou.edu/research.
About the University of Oklahoma
Founded in 1890, the University of Oklahoma is a public research university located in Norman, Oklahoma. OU serves the educational, cultural, economic and health care needs of the state, region and nation. For more information visit www.ou.edu.
