Friday, February 3, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home Latest News

Delivery systems of plasmid DNA and messenger RNA for advanced therapies

April 15, 2022
in Latest News
0
Share on FacebookShare on Twitter

April 15, Kawasaki/Japan

Innovation Center of NanoMedicine (Center Director: Prof. Kazunori Kataoka) has announced that Prof. Satoshi Uchida (Principal Research Scientist), who is also Associated Professor of the Kyoto Prefectural University of Medicine, published an article review about non-viral messenger RNA (mRNA) and plasmid DNA (pDNA) delivery by addressing the various delivery technologies of mRNA and pDNA, from basic research to therapeutic and clinical application; Pharmaceutics 2022, 14(4), 810.

The vast potential of non-viral delivery systems of mRNA and pDNA has been demonstrated in the vaccines against coronavirus disease 2019 (COVID-19). Indeed, two formulations of mRNA vaccines from Pfizer–BioNTech and Moderna were approved for emergency use within one year after the pandemic outbreak, and have been administered to billions of people worldwide. Furthermore, a pDNA vaccine developed by Zydus Cadila also obtained emergency approval in India, exhibiting high efficiency for preventing infection in a large clinical trial. These successful examples prompt further research and the development of vaccines and therapeutics based on mRNA and pDNA. The target areas are not limited to preventive vaccination for infectious diseases but expand to therapeutic cancer vaccines, genome editing, and protein replacement therapy.

However, current non-viral systems need improvement. For example, the relatively intense adverse effects of mRNA vaccines, including myocarditis, provoke vaccine hesitancy and debates about repeated boosting. Thus, safer formulations are in demand for mRNA vaccines to become platforms for various infectious diseases. Meanwhile, therapeutic cancer vaccines require more efficient formulations to overcome the immunosuppressive nature of cancers. For other applications, including genome editing and protein replacement therapy, delivery carriers should reach specific tissues and introduce pDNA and mRNA without damaging the tissues. The present Special Issue addresses vigorous efforts to develop mRNA and pDNA delivery systems and apply them to disease treatment to meet these demands.

The development of non-viral delivery systems has two directions. One focuses on the general improvement of delivery processes, which includes preventing extracellular mRNA and pDNA degradation by nucleases, intracellular targeting of mRNA and pDNA to the desired sites, and prolonging the duration of protein expression from mRNA and pDNA. In the other direction, delivery systems are fine-tuned for specific purposes, such as reaching particular tissues and cells to achieve therapeutic goals and stimulating innate immune systems when used in vaccinations.

This paper provides comprehensive reviews of non-viral mRNA and pDNA delivery by addressing the various delivery technologies of mRNA and pDNA, from basic research to therapeutic and clinical application.



Journal

Pharmaceutics

DOI

10.3390/pharmaceutics14040810

Method of Research

Literature review

Subject of Research

Not applicable

Article Title

Delivery Systems of Plasmid DNA and Messenger RNA for Advanced Therapies

Article Publication Date

7-Apr-2022

COI Statement

The author declare no conflict of interests.

Tags: advanceddeliveryDNAmessengerplasmidRNAsystemstherapies
Share28Tweet18Share5ShareSendShare
  • Face masks cut distance airborne pathogens could travel in half, new study finds

    187 shares
    Share 75 Tweet 47
  • Looking beyond microplastics, Oregon State researchers find that cotton and synthetic microfibers impact behavior and growth of aquatic organisms

    71 shares
    Share 28 Tweet 18
  • Why lung cancer doesn’t respond well to immunotherapy

    65 shares
    Share 26 Tweet 16
  • Null results research now published by major behavioral medicine journal

    551 shares
    Share 220 Tweet 138
  • Discovery of new ice may change understanding of water

    65 shares
    Share 26 Tweet 16
  • Study presents novel therapeutic target for treatment of sepsis

    110 shares
    Share 44 Tweet 28
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

New study shows snacking on mixed tree nuts may impact cardiovascular risk factors and increase serotonin

Null results research now published by major behavioral medicine journal

Face masks cut distance airborne pathogens could travel in half, new study finds

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 205 other subscribers

© 2022 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2022 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In