Friday, June 9, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home Latest News

COVID vaccine induces robust T cell responses in blood cancer patients

March 29, 2023
in Latest News
0
Share on FacebookShare on Twitter

Researchers found that, despite being heavily immunocompromised, haematology patients generate strong cellular immune responses against SARS-CoV-2 after vaccination, on par with that of healthy individuals.

Published today in Cell Reports Medicine, the research team, led by University of Melbourne Professor Katherine Kedzierska, a Laboratory Head at the Peter Doherty Institute for Infection and Immunity (Doherty Institute), undertook the most comprehensive analysis of adaptive SARS-CoV-2 immunity to date in haematology patients of varying diseases and treatments across three doses of COVID-19 vaccination in comparison to healthy individuals. The research was performed in collaboration with Associate Professor Benjamin Teh, Professor Monica Slavin and Professor Constantine Tam from the Peter MacCallum Cancer Centre.

University of Melbourne Dr Oanh Nguyen, Senior Research Fellow at the Doherty Institute and co-lead author of the paper, says it is important to really understand vaccine efficacy in this immunosuppressed high-risk group of patients to help prevent severe SARS-CoV-2 infection.

“This group is at high risk of viral infectious diseases, such as influenza and SARS-CoV-2, and yet they are not always included in pre-clinical trials that test vaccine efficacy,” Dr Nguyen says.

“Our study shows that they highly benefit from receiving three doses of vaccination. The vaccines boost their levels of T cells, the white blood cells that kill viral infected cells, irrespective of the patient’s B-cell numbers and antibody response.

“We also looked at the characteristics of these T cells that are generated after vaccination, and we found that these signatures are very similar to healthy individuals that are either infected or vaccinated. These findings are really important and super exciting for cancer patients,” Dr Nguyen adds.

Professor Kedzierska says that the study provides key insights for future immunisation strategies with vaccines such as influenza which predominantly induce B cell immune responses.

“What we have shown is that people with co-morbidities that have a heavily impacted B cell immune arm, can have an mRNA vaccine to elicit T cells and give them that extra level of protection,” Professor Kedzierska says

Associate Professor Teh says this research is important for clinicians working with blood cancer patients.

“Clinicians can be confident that it is safe and beneficial for their patients, who are heavily immunocompromised and vulnerable to severe COVID-19 infection, to receive vaccination against SARS-CoV-2. Regardless of their diseases and treatments, COVID-19 vaccination generates strong T cell immunity in this group,” Associate Professor Teh says.



Journal

Cell Reports Medicine

DOI

10.1016/j.xcrm.2023.101017

Method of Research

Observational study

Subject of Research

People

Article Title

COVID vaccine induces robust T cell responses in blood cancer patients

COI Statement

Declaration of Interests

The Icahn School of Medicine at Mount Sinai has filed patent applications relating to SARS-CoV-2 serological assays and NDV-based SARS-CoV-2 vaccines which list FK as co-inventor. Mount Sinai has spun out a company, Kantaro, to market serological tests for SARS-CoV-2. FK has consulted for Merck and Pfizer (before 2020), and is currently consulting for Pfizer, Seqirus and Avimex. The Krammer laboratory is also collaborating with Pfizer on animal models of SARS-CoV-2. HAM and BYC are currently consulting for Ena Respiratory. All authors declare no other competing interests. BWT has received research funding from MSD, Seqirus and Sanofi and advisory board for Moderna, CSL-Behring and Takeda.

Tags: bloodcancercellCOVIDinducesPatientsresponsesrobustvaccine
Share27Tweet17Share5ShareSendShare
  • Schrödinger’s cat code

    Schrödinger’s cat makes better qubits

    65 shares
    Share 26 Tweet 16
  • The problems with coal ash start smaller than anyone thought

    67 shares
    Share 27 Tweet 17
  • ‘Revolutionary’ research discovers new cause of cancer coming from inside us

    65 shares
    Share 26 Tweet 16
  • Nearly 70% of private label avocado oil rancid or mixed with other oils

    67 shares
    Share 27 Tweet 17
  • Taurine may be a key to longer and healthier life

    64 shares
    Share 26 Tweet 16
  • Researchers find an immune system ‘trip wire’ that detects COVID-19

    64 shares
    Share 26 Tweet 16
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

UTHSC researchers’ work on human pangenome aids understanding of common chromosomal abnormality

Null results research now published by major behavioral medicine journal

Multiple sclerosis more prevalent in Black Americans than previously thought

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 206 other subscribers

© 2023 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2023 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In