There is no evidence of recently infected mothers transmitting infectious SARS-CoV-2 through breastmilk to their baby, reports a study published in the journal Pediatric Research. The authors found that, whilst a low proportion of breastmilk contained COVID-19 genetic material, this did not translate into the presence of infectious replicating viral particles or lead to evidence of clinical infection with SARS-CoV-2 in breastfeeding infants.
Authors from the University of California (California, USA) analysed breastmilk samples from 110 lactating women who donated to the Mommy’s Milk Human Milk Biorepository at the University of California, San Diego between March and September 2020. Of the 110 women included, 65 had a positive COVID-19 test, while 9 had symptoms but tested negative, and 36 were symptomatic but were not tested.
Paul Krogstad and colleagues found SARS-CoV-2 genetic material (RNA) in the breastmilk of 7 women (6%) with either confirmed infection or who reported being symptomatic. A second breastmilk sample taken from these 7 women between one and 97 days later did not contain any SARS-CoV-2 RNA. The authors did not find any infectious SARS-CoV-2 genetic material known as SgRNA, which is an indicator of virus replication, in the 7 breastmilk samples and when culturing other samples. There was no clinical evidence of infection in the infants who were breastfed by the 7 mothers with SARS-CoV-2 RNA in their milk.
The authors caution that the sample size is low in this study and may not capture all the potential factors that predict the presence of SARS-CoV-2 RNA in breastmilk. However, it is the largest study at this time to analyse breastmilk and provides evidence that breastfeeding from women proven or suspected to have had SARS-CoV-2 infection does not lead to COVID-19 infection in their infants.
Paul Krogstad, lead author, said: “Breastmilk is an invaluable source of nutrition to infants. In our study, we found no evidence that breastmilk from mothers infected with COVID-19 contained infectious genetic material and no clinical evidence was found to suggest the infants got infected, which suggests breastfeeding is not likely to be a hazard.”
The authors conclude that their study adds to the evidence that women who are infected with COVID-19 and are breastfeeding their child have no risk of transmitting the virus through their breastmilk.
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No infectious SARS-CoV-2 in breast milk from a cohort of 110 lactating women
Paul Krogstad et al.
Pediatric Research 2022
DOI: 10.1038/s41390-021-01902-y
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3. Pediatric Research publishes original translational research papers, invited reviews, and commentaries on the etiologies and treatment of diseases of children and disorders of development, extending from basic science to epidemiology and quality improvement.
Journal
Pediatric Research
DOI
10.1038/s41390-021-01902-y
