Wednesday, October 4, 2023
SCIENMAG: Latest Science and Health News
No Result
View All Result
  • Login
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US
No Result
View All Result
Scienmag - Latest science news from science magazine
No Result
View All Result
Home SCIENCE NEWS Social & Behavioral Science

Clinical trial for new innovative osteoarthritis drug

February 16, 2017
in Social & Behavioral Science
0
Share on FacebookShare on Twitter

The University of Liverpool, in partnership with AKL Research and Development Ltd, is to lead on a clinical trial to test a potential new drug treatment for osteoarthritis.

Osteoarthritis (OA) is the most common type of arthritis in the UK, affecting more than eight million people*, and is the leading cause of joint pain and stiffness in older people.

As part of their research and development programme, AKL identifies promising phytochemicals, found in natural products, which are capable of being synthesized.

Trials have identified two molecules which act synergistically and have been brought together to create 'APPA', a patented drug.

Improved functionality

In a variety of pre-clinical animal testing trials, APPA has clearly demonstrated significant pain relief from OA, improved functionality and the slowing of cartilage destruction.

Having successfully passed preclinical toxicology studies, formal human studies can now start.

The clinical trial is due to commence shortly at the Liverpool Clinical Trials Unit (LCTU) led by rheumatologist Professor Robert Moots from the University's Institute of Ageing and Chronic Disease.

'Huge potential'

Professor Moots, said: "The severe pain from OA is usually managed with prescription drugs that are often not effective and that also, in many cases, induce unacceptable side effects. In many cases, major joint replacement surgery is needed to help deal with the pain. This is surely wrong.

"This drug has huge potential to provide an effective treatment for OA. A reliable and easy way to treat OA has clear potential to save large amounts of money for the NHS and greatly improve the lifestyle and health of patients.

"Working with research and development companies like AKL is crucial for the development and introduction of new treatments to benefit patients now and in future generations. We are excited to move this programme of trials forward."

'holy grail'

Research on how APPA affects human cells, especially activated neutrophils, is being led by Professor Steven Edwards at the University's Institute of Integrative Biology.

Professor Edwards, said: "Neutrophils are the most abundant type of white blood cells and form an essential part of our immune system. There is now considerable evidence to show that neutrophils are activated in inflammatory diseases. They are however a "two-edged sword": they are required to protect us from infections but their inappropriate activation can result in irreversible damage in inflammatory diseases.

"The 'holy grail' of anti-inflammatory targeting of neutrophils is specifically to block their tissue-damaging activities, but not compromise their ability to protect us. Work is ongoing but to date it appears that APPA does not target the host defence properties of neutrophils but does block their pro-inflammatory activities".

David Sharples, CEO, AKL, said: "Professor Moots is leading this important clinical trial and that, in conjunction with Professor Edwards' research on APPA's novel modes of action, should provide the robust evidence we need to help bring this drug to market. There remains a high unmet need for an effective, well tolerated OA drug, so understandably we are very excited by APPA's prospects".

###

Editors Notes

  • According to Arthritis Research UK 8.75 million people in the UK have sought treatment for osteoarthritis.

This means:

  • 33% of people aged 45 years and over
  • 49% of women and 42% of men of those aged 75 years and over

AKL COMPANY INFO

AKL Research & Development Limited ("AKL") is an emerging pharmaceutical development company with a pioneering approach to drug development. AKL identifies and validates the active phytochemicals found in natural products. Synthetic versions of these compounds, whose safety and efficacy in their natural form have already been established in non-prescription markets are then taken to proof of concept through robust clinical evaluation.

AKL's strategy of using well-characterised active compounds considerably improves the chances of successfully completing preclinical toxicity studies, avoiding unexpected side effects and demonstrating efficacy. It is AKL's intention to access global markets via a partner following proof of concept.

The Company is based at the Stevenage Bioscience Catalyst, Stevenage, Herts UK. http://www.aklrd.com

Professor Moots combines his clinical work as a consultant rheumatologist at Aintree University Hospital, with internationally recognised research into the causes and treatment of rheumatic diseases. Recently his group has been designated as a European Centre of Excellence for Rheumatology Research.

Professor Steven Edwards is the Professor of Biochemistry at the Institute of Integrative Biology, University of Liverpool.

Media Contact

Simon Wood
simon.wood@liverpool.ac.uk
44-151-794-8356
@livuninews

http://www.liv.ac.uk

Share25Tweet16Share4ShareSendShare
  • New $81million NIH grant will help U.S. answer urgent need for better dementia care

    72 shares
    Share 29 Tweet 18
  • New research finds that ancient carbon in rocks releases as much carbon dioxide as the world’s volcanoes

    70 shares
    Share 28 Tweet 18
  • Instant evolution: AI designs new robot from scratch in seconds

    69 shares
    Share 28 Tweet 17
  • IU cancer researcher receives $2.2 million grant for metastatic breast cancer research

    69 shares
    Share 28 Tweet 17
  • The World Mitochondria Society will host Targeting Mitochondria 2023 with challenging visions in Berlin

    66 shares
    Share 26 Tweet 17
  • Globally, consumption of sugary drinks increased at least 16% since 1990

    65 shares
    Share 26 Tweet 16
ADVERTISEMENT

About us

We bring you the latest science news from best research centers and universities around the world. Check our website.

Latest NEWS

Null results research now published by major behavioral medicine journal

Groundbreaking mathematical proof: new insights into typhoon dynamics unveiled

New $81million NIH grant will help U.S. answer urgent need for better dementia care

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 208 other subscribers

© 2023 Scienmag- Science Magazine: Latest Science News.

No Result
View All Result
  • HOME PAGE
  • BIOLOGY
  • CHEMISTRY AND PHYSICS
  • MEDICINE
    • Cancer
    • Infectious Emerging Diseases
  • SPACE
  • TECHNOLOGY
  • CONTACT US

© 2023 Scienmag- Science Magazine: Latest Science News.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In